Jung K Y, Warter S, Rumpler Y
Institut d'Embryologie, Faculté de Médecine, Strasbourg, France.
Cytogenet Cell Genet. 1991;57(1):59-62. doi: 10.1159/000133116.
A human genomic DNA sequence derived from glutamate dehydrogenase pseudogene 1 was used as a probe for in situ hybridization to the chromosomes of three lemur species, Eulemur fulvus mayottensis (EFU), E. macaco macaco (EMA), and E. coronatus (ECO). This sequence, which is 98% homologous to the nucleotide sequence of the gene for human glutamate dehydrogenase (GLUD), was found on homologous bands of three morphologically similar chromosome segments, EFU14, EMA5p, and ECO8q, confirming that different Robertsonian translocations occurred during the evolution of these three species. These loci on the lemur chromosomes probably correspond to the human GLUD locus.
一段源自谷氨酸脱氢酶假基因1的人类基因组DNA序列被用作探针，对三种狐猴物种——马约特褐狐猴（EFU）、黑冠猕猴（EMA）和冠美狐猴（ECO）的染色体进行原位杂交。该序列与人类谷氨酸脱氢酶（GLUD）基因的核苷酸序列具有98%的同源性，在三个形态相似的染色体片段的同源带——EFU14、EMA5p和ECO8q上被发现，这证实了在这三个物种的进化过程中发生了不同的罗伯逊易位。狐猴染色体上的这些位点可能对应于人类GLUD位点。
