通过芳基羧酸与三氟甲磺酸二芳基碘鎓盐的脱羧钯催化反应合成联芳基化合物。

Biaryl synthesis via decarboxylative Pd-catalyzed reactions of arenecarboxylic acids and diaryliodonium triflates.

作者信息

Becht Jean-Michel, Le Drian Claude

机构信息

Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, Laboratoire de Chimie Organique et Bioorganique, UMR-CNRS, Mulhouse cedex, France.

出版信息

Org Lett. 2008 Jul 17;10(14):3161-4. doi: 10.1021/ol8011293. Epub 2008 Jun 14.

DOI:10.1021/ol8011293

PMID:18553969

Abstract

A novel simple and efficient synthesis of biaryls via a Pd-catalyzed decarboxylative cross-coupling reaction of arenecarboxylic acids and diaryliodonium triflates is described. The PdCl2/DPEphos catalytic system in the presence of Ag2CO3 in DMSO was found to be the most efficient. Various biaryls, including sterically hindered biaryls, were synthesized with yields ranging from 37 to 85%.

摘要

描述了一种通过钯催化的芳酸与三氟甲磺酸二芳基碘鎓盐的脱羧交叉偶联反应来合成联芳基化合物的新颖、简单且高效的方法。发现在二甲基亚砜中，碳酸银存在下的PdCl₂/DPEphos催化体系是最有效的。合成了各种联芳基化合物，包括位阻联芳基化合物，产率范围为37%至85%。