Nogueira-Machado José Augusto, Chaves Miriam Martins
Hospital Santa Casa de Belo Horizonte, Núcleo de Pesquisa e Pós-Graduação, Avenue Francisco Sales, 1111, 30250-330, Belo Horizonte, MG, Brazil.
Expert Opin Ther Targets. 2008 Jul;12(7):871-82. doi: 10.1517/14728222.12.7.871.
Diabetes mellitus constitutes a serious public health problem. Recent advances in therapies are unable to control its vascular complications. New medications have been suggested but without comprehensive knowledge of the signaling pathways induced by hyperglycemia.
To review the mechanisms of the inducer and effector phases of the metabolic cascade in diabetes, with emphasis on the steps that have been targeted to date The route from hyperglycemia to advanced glycation end products (AGE)-receptor of advanced glycation end products (RAGE) complex formation is suggested as a target for new therapies.
A review of literature, including historical papers and recent manuscripts.
All the components of the suggested route are initially activated or indirectly formed due to hyperglycemia via a two-phase cascade that represents a dangerous metabolic route, especially for diabetics. Recent experiments with new drugs and clinical trials targeting this pathway are examined.
In order to control vascular injury in diabetes, several steps in the cascade need to be inhibited simultaneously together with aggressive glycemic control.
糖尿病是一个严重的公共卫生问题。目前治疗方法的进展无法控制其血管并发症。已提出了新的药物，但对高血糖诱导的信号通路缺乏全面了解。
综述糖尿病代谢级联反应诱导期和效应期的机制，重点关注迄今已作为靶点的步骤。从高血糖到晚期糖基化终产物（AGE）-晚期糖基化终产物受体（RAGE）复合物形成的途径被认为是新疗法的靶点。
对文献进行综述，包括历史文献和近期手稿。
所建议途径的所有成分最初都是由于高血糖通过两阶段级联反应被激活或间接形成的，这代表了一条危险的代谢途径，对糖尿病患者尤其如此。研究了针对该途径的新药近期实验和临床试验。
为了控制糖尿病中的血管损伤，除了积极控制血糖外，还需要同时抑制级联反应中的几个步骤。
