Schmidt A M, Stern D M
College of Physicians & Surgeons, 630 West 168th Street, P&S 17-501, Columbia University, New York, NY 10032, USA.
Trends Endocrinol Metab. 2000 Nov;11(9):368-75. doi: 10.1016/s1043-2760(00)00311-8.
Although the underlying causes of hyperglycemia are multiple, a common thread associated with high levels of blood sugar is the development of a range of vascular and inflammatory complications that might seriously limit the quality and duration of life in affected individuals. Despite multiple aggressive efforts to prevent complications, diabetes remains the leading disease consuming healthcare dollars in the USA. This review focuses on the role of advanced glycation endproducts (AGEs) and their interaction with their signal-transduction AGE receptor (RAGE), in vascular and inflammatory cell perturbation and the chronic activation that underlies diabetes. Our studies provide mechanistic insights into complications within the macrovasculature and those ensuing from an exaggerated host response to invading bacteria, and suggest that blockade of RAGE might provide a potent and safe strategy for the prevention of complications that typify long-term diabetes.
尽管高血糖的潜在病因多种多样，但与高血糖水平相关的一个共同因素是一系列血管和炎症并发症的发生，这些并发症可能会严重限制患者的生活质量和寿命。尽管为预防并发症做出了多项积极努力，但糖尿病仍是美国消耗医疗保健费用最多的主要疾病。本综述重点关注晚期糖基化终产物（AGEs）及其与信号转导AGE受体（RAGE）的相互作用在血管和炎症细胞扰动以及糖尿病潜在的慢性激活中的作用。我们的研究为大血管并发症以及因宿主对入侵细菌的过度反应而引发的并发症提供了机制性见解，并表明阻断RAGE可能为预防典型的长期糖尿病并发症提供一种有效且安全的策略。
