Tsekouras Yiannis E, Magkos Faidon, Prentzas Konstantinos I, Basioukas Konstantinos N, Matsama Stergoula G, Yanni Amalia E, Kavouras Stavros A, Sidossis Labros S
Department of Nutrition and Dietetics, Harokopio University, 70 El. Venizelou Avenue, 17671 Athens, Greece.
Clin Sci (Lond). 2009 Jan;116(2):147-56. doi: 10.1042/CS20080078.
A single bout of prolonged aerobic exercise lowers plasma TAG (triacylglycerol) concentrations the next day by increasing the efficiency of VLDL (very-low-density lipoprotein)-TAG removal from the circulation. The effect of resistance exercise on VLDL-TAG metabolism is not known. Therefore we evaluated VLDL-TAG kinetics by using stable isotope-labelled tracers in eight healthy untrained men (age, 25.3+/-0.8 years; body mass index, 24.5+/-0.6 kg/m(2)) in the post-absorptive state in the morning on two separate occasions: once after performing a single 90-min bout of strenuous isokinetic resistance exercise (three sets x ten repetitions, 12 exercises at 80% of maximum peak torque production, with a 2-min rest interval between exercises) on the preceding afternoon and once after an equivalent period of rest. Fasting plasma VLDL-TAG concentrations in the morning after exercise were significantly lower than in the morning after rest (0.23+/-0.04 compared with 0.33+/-0.06 mmol/l respectively; P=0.001). Hepatic VLDL-TAG secretion rate was not different (P=0.31), but plasma clearance rate of VLDL-TAG was significantly higher (by 26+/-8%) after exercise than rest (31+/-3 compared with 25+/-3 ml/min respectively; P=0.004), and the mean residence time of VLDL-TAG in the circulation was significantly shorter (113+/-10 compared with 144+/-18 min respectively; P=0.02). Fasting plasma NEFA (non-esterified fatty acid; 'free' fatty acid) and serum beta-hydroxybutyrate concentrations were both significantly higher after exercise than rest (P<0.05), whereas plasma glucose and serum insulin concentrations were not different (P>0.30). We conclude that, in healthy untrained men, a single bout of whole-body resistance exercise lowers fasting plasma VLDL-TAG concentrations by augmenting VLDL-TAG removal from plasma. The effect appears to be qualitatively and quantitatively similar to that reported previously for aerobic exercise.
单次长时间有氧运动通过提高极低密度脂蛋白（VLDL）-甘油三酯（TAG）从循环中清除的效率，可使次日血浆TAG浓度降低。抗阻运动对VLDL-TAG代谢的影响尚不清楚。因此，我们在8名健康的未经训练的男性（年龄25.3±0.8岁；体重指数24.5±0.6kg/m²）处于空腹状态的上午，分两次使用稳定同位素标记示踪剂评估VLDL-TAG动力学：一次是在前一天下午进行单次90分钟的剧烈等动抗阻运动（三组，每组十次重复，12项运动，运动强度为最大峰值扭矩产生的80%，组间休息2分钟）之后，另一次是在同等休息期之后。运动后早晨的空腹血浆VLDL-TAG浓度显著低于休息后早晨的浓度（分别为0.23±0.04与0.33±0.06mmol/L；P=0.001）。肝VLDL-TAG分泌率无差异（P=0.31），但运动后VLDL-TAG的血浆清除率显著高于休息后（分别为31±3与25±3ml/min，提高了26±8%；P=0.004），且VLDL-TAG在循环中的平均停留时间显著缩短（分别为113±10与144±18分钟；P=0.02）。运动后空腹血浆非酯化脂肪酸（NEFA；“游离”脂肪酸）和血清β-羟基丁酸浓度均显著高于休息后（P<0.05），而血浆葡萄糖和血清胰岛素浓度无差异（P>0.30）。我们得出结论，在健康的未经训练的男性中，单次全身抗阻运动通过增加血浆中VLDL-TAG的清除，降低空腹血浆VLDL-TAG浓度。这种作用在性质和数量上似乎与先前报道的有氧运动相似。
