Seyhan E C, Cetinkaya E, Altin S, Gunluoglu M Z, Demir A, Koksal V, Issever H
Department of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey.
Tissue Antigens. 2008 Aug;72(2):162-5. doi: 10.1111/j.1399-0039.2008.01076.x. Epub 2008 Jun 28.
Polymorphism at +813 locus of vascular endothelial growth factor (VEGF) gene is considered to decrease predisposition to sarcoidosis. Our study aimed to investigate the roles of this polymorphism in the development and extent of sarcoidosis. We examined polymorphisms of the VEGF gene in 90 cases with histopathological diagnosis of sarcoidosis and in 110 healthy subjects. VEGF +813 gene polymorphisms were determined using a polymerase chain reaction-based method after DNA isolation. A significant increase in the frequency of the T allele was found in healthy subjects (odds ratio 0.55; 95% confidence interval 0.32-0.97, P<0.05). Our results suggest that increase in rarer T allele at + 813 locus of VEGF gene may diminish susceptibility to sarcoidosis in Turkish population.
血管内皮生长因子（VEGF）基因+813位点的多态性被认为可降低结节病的易感性。我们的研究旨在探讨这种多态性在结节病发生发展及严重程度中的作用。我们检测了90例经组织病理学诊断为结节病的患者以及110名健康对照者的VEGF基因多态性。DNA提取后，采用基于聚合酶链反应的方法确定VEGF +813基因多态性。健康对照者中T等位基因频率显著升高（优势比0.55；95%置信区间0.32 - 0.97，P<0.05）。我们的结果表明，VEGF基因+813位点罕见的T等位基因增加可能会降低土耳其人群患结节病的易感性。
