感染HIV或有感染风险的老年男性甲状腺功能异常。
Abnormal thyroid function in older men with or at risk for HIV infection.
作者信息
Wiener M, Lo Y, Klein R S
机构信息
Department of Special Services, North General Hospital, New York, NY, USA.
出版信息
HIV Med. 2008 Aug;9(7):544-9. doi: 10.1111/j.1468-1293.2008.00601.x. Epub 2008 Jun 7.
OBJECTIVES
The aim of the study was to evaluate the prevalence of and factors associated with abnormal thyroid function in older men with or at risk for HIV infection.
METHODS
A cross-sectional analysis of 636 men > or =49 years old was carried out using data obtained from interviews, from measurements of body mass index (BMI), HIV-1 serology and viral load, CD4 cell count, hepatitis C virus (HCV) assays, thyroid-stimulating hormone (TSH) and free thyroid hormone levels.
RESULTS
Participants were 54% black, 57% overweight/obese, 57% HIV seropositive, and 72% HCV seropositive; 38% reported recent cocaine or heroin use. Decreased TSH was found in 56 men (8.8%) and raised TSH in 23 men (3.6%). Only three men had abnormal free thyroxine levels.
CONCLUSIONS
Abnormal TSH levels were noted in 12.4% of older men with or at risk for HIV infection, but nearly all reflected subclinical hyperthyroidism or subclinical hypothyroidism.
目的
本研究旨在评估感染HIV或有感染风险的老年男性甲状腺功能异常的患病率及其相关因素。
方法
对636名年龄≥49岁的男性进行横断面分析，数据来自访谈、体重指数（BMI）测量、HIV-1血清学和病毒载量检测、CD4细胞计数、丙型肝炎病毒（HCV）检测、促甲状腺激素（TSH）和游离甲状腺激素水平测定。
结果
参与者中54%为黑人，57%超重/肥胖，57%HIV血清学阳性，72%HCV血清学阳性；38%报告近期使用过可卡因或海洛因。56名男性（8.8%）促甲状腺激素降低，23名男性（3.6%）促甲状腺激素升高。只有3名男性游离甲状腺素水平异常。
结论
12.4%感染HIV或有感染风险的老年男性促甲状腺激素水平异常，但几乎所有异常都反映为亚临床甲状腺功能亢进或亚临床甲状腺功能减退。
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