[癫痫患儿的发作间期癫痫样放电]

[Interictal epileptiform discharges in children with epilepsy].

作者信息

Xiao Yu-Han, Liao Jian-Xiang, Huang Juan, Mai Jian-Ning

机构信息

Department of Neurology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518026, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2008 Jun;10(3):322-4.

PMID:18554459

Abstract

OBJECTIVE

To study the features of interictal epileptiform discharges (IED) during sleep and wakefulness in children with epilepsy.

METHODS

The polysomnography, active EEG and video EEG were performed on 48 children with epilepsy during the whole night, and wakefulness of pre- and post-sleep. The epileptiform sharp/spike discharge indexes during sleep and wakefulness were recorded. The positive rate of IED in focal and generalized epilepsy was compared.

RESULTS

Of the 48 patients, 25 showed IED, including 9 cases (36.0%) in the generalized seizure group and 16 cases (64.0%) in the focal seizure group (P<0.05). The epileptiform sharp/spike discharge indexes in the whole non-rapid eye movement (NREM) sleep stage (stages S1-S4: 21.13+/-19.96, 19.59+/-17.76, 22.85+/-18.99, and 20.37+/-16.63) were significantly higher than that in the wakefulness stage (8.20+/-6.21) (P<0.05). The discharge index in the S3 stage during NREM sleep was higher than that during the rapid eye movement (REM) sleep (22.85+/-18.99 vs 12.91+/-10.95; P<0.05).

CONCLUSIONS

The positive rate of IED in the focal seizure group was higher than that in the generalized seizure group. Sleep, especially NREM sleep, facilitates IED in children with epilepsy.

摘要

目的

研究癫痫患儿睡眠期和清醒期发作间期癫痫样放电（IED）的特征。

方法

对48例癫痫患儿进行整夜多导睡眠图、动态脑电图及视频脑电图监测，记录睡眠前后的清醒状态。记录睡眠期和清醒期的癫痫样棘波/尖波放电指数。比较局灶性癫痫和全身性癫痫中IED的阳性率。

结果

48例患者中，25例出现IED，其中全身性发作组9例（36.0%），局灶性发作组16例（64.0%）（P<0.05）。整个非快速眼动（NREM）睡眠阶段（S1-S4期：21.13±19.96、19.59±17.76、22.85±18.99和20.37±16.63）的癫痫样棘波/尖波放电指数显著高于清醒期（8.20±6.21）（P<0.05）。NREM睡眠期S3期的放电指数高于快速眼动（REM）睡眠期（22.85±18.99对12.91±10.95；P<0.05）。