Tangri Vikram, Chande Nilesh
Department of Medicine, The University of Western Ontario, Canada.
J Clin Gastroenterol. 2009 Apr;43(4):293-6. doi: 10.1097/MCG.0b013e31818f50ce.
Microscopic colitis (MC) causes chronic diarrhea, abdominal cramping, nausea, and weight loss. Colonic mucosa appears normal on endoscopy; however, biopsies show abnormalities such as intraepithelial lymphocytosis in lymphocytic colitis, and a thickened subepithelial collagen band in collagenous colitis. Epidemiologic data demonstrates that MC is a more common cause of diarrhea than previously shown. Although the etiology of this condition is unclear, certain well-defined risk factors exist. Recently there has been more research on the pathophysiology of MC, and studies on treatment have demonstrated budesonide to be most effective, although other treatments also hold promise.
显微镜下结肠炎（MC）可导致慢性腹泻、腹部绞痛、恶心和体重减轻。结肠镜检查时结肠黏膜外观正常；然而，活检显示存在异常，如淋巴细胞性结肠炎中的上皮内淋巴细胞增多，以及胶原性结肠炎中的上皮下胶原带增厚。流行病学数据表明，MC是比以往所显示的更为常见的腹泻病因。尽管这种疾病的病因尚不清楚，但存在某些明确的危险因素。最近对MC的病理生理学有了更多研究，关于治疗的研究表明布地奈德最为有效，不过其他治疗方法也有前景。
