Maliqueo Manuel, Echiburú Bárbara, Crisosto Nicolás, Amigo Pablo, Aranda Pablo, Sánchez Fernando, Sir-Petermann Teresa
Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile.
Fertil Steril. 2009 Jul;92(1):277-82. doi: 10.1016/j.fertnstert.2008.04.022. Epub 2008 Jun 13.
To assess metabolic parameters in the cord blood of newborns of women with polycystic ovary syndrome (PCOS) and to correlate these parameters with those of mothers with PCOS during midgestation.
Case-control study.
Unit of Endocrinology and Reproductive Medicine.
PATIENT(S): Thirty newborns of mothers with PCOS (PCOSn) and 34 newborns of control mothers (Cn) were studied.
INTERVENTION(S): A sample of cord blood was obtained at delivery. In all mothers, an oral glucose tolerance test (oGTT) with measurement of glucose and insulin was performed at 22-28 weeks of gestation. In cord blood and in the fasting sample of the oGTT, serum leptin, adiponectin, insulin, glucose, and lipids (triglycerides, cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol) were determined.
RESULT(S): PCOSn showed significantly higher leptin concentrations than Cn. Moreover, in PCOSn, leptin concentrations in cord blood were correlated with birth weight (r = 0.495) and body mass index of the mother at midpregnancy (r = 0.644).
CONCLUSION(S): The metabolic parameters in the cord blood of PCOSn are similar to those observed in controls, except for leptin concentrations, which are significantly higher. The latter could be related to the fetal adiposity or the metabolic condition of the mother.
评估多囊卵巢综合征（PCOS）女性新生儿脐血中的代谢参数，并将这些参数与妊娠中期患有PCOS的母亲的参数进行关联分析。
病例对照研究。
内分泌与生殖医学科。
研究了30名患有PCOS母亲的新生儿（PCOSn）和34名对照母亲的新生儿（Cn）。
分娩时采集脐血样本。所有母亲在妊娠22 - 28周时进行口服葡萄糖耐量试验（oGTT），并测量葡萄糖和胰岛素水平。测定脐血和oGTT空腹样本中的血清瘦素、脂联素、胰岛素、葡萄糖和脂质（甘油三酯、胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇）。
PCOSn的瘦素浓度显著高于Cn。此外，在PCOSn中，脐血中的瘦素浓度与出生体重（r = 0.495）和母亲妊娠中期的体重指数（r = 0.644）相关。
除瘦素浓度显著较高外，PCOSn脐血中的代谢参数与对照组相似。后者可能与胎儿肥胖或母亲的代谢状况有关。
