氧化甘油磷胆碱作为紫外线辐射介导效应的生物活性介质。
Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects.
作者信息
Konger Raymond L, Marathe Gopal K, Yao Yongxue, Zhang Qiwei, Travers Jeffrey B
机构信息
Department of Pathology, Indiana University, Indianapolis, IN 46202, USA.
出版信息
Prostaglandins Other Lipid Mediat. 2008 Dec;87(1-4):1-8. doi: 10.1016/j.prostaglandins.2008.04.002. Epub 2008 May 2.
Abstract
Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. Inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). Importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation.
摘要
紫外线辐射（UVR）对人体皮肤有深远影响。然而，UVR的确切作用靶点尚不清楚。鉴于UVR是一种已知的促氧化应激源，UVR的一个潜在靶点可能是氧化修饰的甘油磷酸胆碱（GPC）。重要的是，最近的研究表明，这些氧化型GPC（ox-GPC）是血小板活化因子受体和过氧化物酶体增殖物激活受体γ的强效激动剂。本文综述了这些新的生物活性脂质及其下游受体靶点，它们提供了一个独特的生物传感器系统，用于检测和响应UVR光氧化。
相似文献
1
Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects.
Prostaglandins Other Lipid Mediat. 2008 Dec;87(1-4):1-8. doi: 10.1016/j.prostaglandins.2008.04.002. Epub 2008 May 2.
2
Epidermal peroxisome proliferator-activated receptor gamma as a target for ultraviolet B radiation.
J Biol Chem. 2005 Jan 7;280(1):73-9. doi: 10.1074/jbc.M409795200. Epub 2004 Oct 29.
3
The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists.
Carcinogenesis. 2012 Jul;33(7):1360-7. doi: 10.1093/carcin/bgs152. Epub 2012 Apr 27.
4
Acute Ethanol Exposure Augments Low-Dose UVB-Mediated Systemic Immunosuppression via Enhanced Production of Platelet-Activating Factor Receptor Agonists.
J Invest Dermatol. 2019 Jul;139(7):1619-1622. doi: 10.1016/j.jid.2018.11.034. Epub 2019 Jan 23.
5
Acute keratinocyte damage stimulates platelet-activating factor production.
Arch Dermatol Res. 2000 May;292(5):256-9. doi: 10.1007/s004030050483.
6
Platelet-Activating Factor as an Effector for Environmental Stressors.
Handb Exp Pharmacol. 2020;259:185-203. doi: 10.1007/164_2019_218.
7
Sebum, inflammasomes and the skin: current concepts and future perspective.
Exp Dermatol. 2015 Sep;24(9):651-4. doi: 10.1111/exd.12774. Epub 2015 Jul 14.
8
Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver.
J Lipid Res. 2001 Apr;42(4):587-96.
9
Radiation therapy generates platelet-activating factor agonists.
Oncotarget. 2016 Apr 12;7(15):20788-800. doi: 10.18632/oncotarget.7878.
10
Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines.
J Biol Chem. 1999 Oct 1;274(40):28395-404. doi: 10.1074/jbc.274.40.28395.
引用本文的文献
1
Impact of targeting the platelet-activating factor and its receptor in cancer treatment.
Mil Med Res. 2025 Mar 4;12(1):10. doi: 10.1186/s40779-025-00597-0.
2
Relevance of the Platelet-activating factor system in chemical warfare agents-induced effects.
Free Radic Biol Med. 2025 Feb 16;228:62-67. doi: 10.1016/j.freeradbiomed.2024.12.037. Epub 2024 Dec 18.
3
UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment.
Front Immunol. 2022 May 6;13:880850. doi: 10.3389/fimmu.2022.880850. eCollection 2022.
4
New Insights Into the Pathologic Roles of the Platelet-Activating Factor System.
Front Endocrinol (Lausanne). 2021 Mar 15;12:624132. doi: 10.3389/fendo.2021.624132. eCollection 2021.
5
The Skin Epilipidome in Stress, Aging, and Inflammation.
Front Endocrinol (Lausanne). 2021 Jan 21;11:607076. doi: 10.3389/fendo.2020.607076. eCollection 2020.
6
Platelet-Activating Factor-Receptor Signaling Mediates Targeted Therapies-Induced Microvesicle Particles Release in Lung Cancer Cells.
Int J Mol Sci. 2020 Nov 12;21(22):8517. doi: 10.3390/ijms21228517.
7
Thermal Burn Injury Generates Bioactive Microvesicles: Evidence for a Novel Transport Mechanism for the Lipid Mediator Platelet-Activating Factor (PAF) That Involves Subcellular Particles and the PAF Receptor.
J Immunol. 2020 Jul 1;205(1):193-201. doi: 10.4049/jimmunol.1901393. Epub 2020 May 20.
8
Platelet-Activating Factor as an Effector for Environmental Stressors.
Handb Exp Pharmacol. 2020;259:185-203. doi: 10.1007/164_2019_218.
9
Acute Ethanol Exposure Augments Low-Dose UVB-Mediated Systemic Immunosuppression via Enhanced Production of Platelet-Activating Factor Receptor Agonists.
J Invest Dermatol. 2019 Jul;139(7):1619-1622. doi: 10.1016/j.jid.2018.11.034. Epub 2019 Jan 23.
10
A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids.
Redox Biol. 2019 Jan;20:467-482. doi: 10.1016/j.redox.2018.11.006. Epub 2018 Nov 13.
本文引用的文献
1
UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system.
J Invest Dermatol. 2008 Jul;128(7):1780-7. doi: 10.1038/sj.jid.5701251. Epub 2008 Jan 17.
2
Augmentation of UVB radiation-mediated early gene expression by the epidermal platelet-activating factor receptor.
J Invest Dermatol. 2008 Feb;128(2):455-60. doi: 10.1038/sj.jid.5701083. Epub 2007 Oct 11.
3
Biology of PPAR gamma in cancer: a critical review on existing lacunae.
Curr Mol Med. 2007 Sep;7(6):532-40. doi: 10.2174/156652407781695765.
4
15-Deoxy-delta 12,14-prostaglandin J2 (15d-PGJ 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation.
Apoptosis. 2007 Nov;12(11):2101-14. doi: 10.1007/s10495-007-0124-2.
5
15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells.
J Neuroinflammation. 2007 Jul 16;4:18. doi: 10.1186/1742-2094-4-18.
6
15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells.
Toxicol Appl Pharmacol. 2007 Aug 15;223(1):20-7. doi: 10.1016/j.taap.2007.04.019. Epub 2007 Jun 8.
7
Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt.
Shock. 2007 Nov;28(5):554-63. doi: 10.1097/shk.0b013e31804f56b9.
8
PPARgamma in human and mouse physiology.
Biochim Biophys Acta. 2007 Aug;1771(8):999-1013. doi: 10.1016/j.bbalip.2007.03.006. Epub 2007 Mar 27.
9
n-3 and n-6 polyunsaturated fatty acids induce the expression of COX-2 via PPARgamma activation in human keratinocyte HaCaT cells.
Biochim Biophys Acta. 2007 May;1771(5):576-89. doi: 10.1016/j.bbalip.2007.02.014. Epub 2007 Mar 16.
10
Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells.
J Biol Chem. 2007 Jun 8;282(23):16934-41. doi: 10.1074/jbc.M702523200. Epub 2007 Apr 20.
Zotero 插件