Christian Doppler Laboratory for Skin Multimodal Imaging of Aging and Senescence - SKINMAGINE -, Vienna, Austria.
Christian Doppler Laboratory on Biotechnology of Skin Aging, Vienna, Austria.
Front Endocrinol (Lausanne). 2021 Jan 21;11:607076. doi: 10.3389/fendo.2020.607076. eCollection 2020.
Lipids are highly diverse biomolecules crucial for the formation and function of cellular membranes, for metabolism, and for cellular signaling. In the mammalian skin, lipids additionally serve for the formation of the epidermal barrier and as surface lipids, together regulating permeability, physical properties, acidification and the antimicrobial defense. Recent advances in accuracy and specificity of mass spectrometry have allowed studying enzymatic and non-enzymatic modifications of lipids-the epilipidome-multiplying the known diversity of molecules in this class. As the skin is an organ that is frequently exposed to oxidative-, chemical- and thermal stress, and to injury and inflammation, it is an ideal organ to study epilipidome dynamics, their causes, and their biological consequences. Recent studies uncover loss or gain in biological function resulting from either specific modifications or the sum of the modifications of lipids. These studies suggest an important role for the epilipidome in stress responses and immune regulation in the skin. In this minireview we provide a short survey of the recent developments on causes and consequences of epilipidomic changes in the skin or in cell types that reside in the skin.
脂质是高度多样化的生物分子，对细胞膜的形成和功能、代谢以及细胞信号转导至关重要。在哺乳动物的皮肤中，脂质还可以形成表皮屏障和表面脂质，共同调节通透性、物理性质、酸化和抗菌防御。质谱技术在准确性和特异性方面的最新进展使得研究脂质的酶和非酶修饰（即表皮脂质组学）——这使得该类分子的已知多样性倍增。由于皮肤是经常受到氧化、化学和热应激以及损伤和炎症影响的器官，因此它是研究表皮脂质组学动态、其原因及其生物学后果的理想器官。最近的研究揭示了由于特定修饰或脂质修饰总和导致的生物功能丧失或获得。这些研究表明，表皮脂质组在皮肤的应激反应和免疫调节中起着重要作用。在这篇简评中，我们对皮肤或存在于皮肤中的细胞类型中表皮脂质组学变化的原因和后果的最新进展进行了简要概述。
