Hassen-Zrour S, Younes M, Haj Salah-Othman M, Korbäa W, Touzi M, Béjia I, Bergaoui N, Hamdi M F
Service de Rhumatologie, EPS de Monastir, Monastir, Tunisia.
Chir Main. 2008 Apr-Jun;27(2-3):122-5. doi: 10.1016/j.main.2008.04.002. Epub 2008 May 7.
Tuberculous dactylitis (TD) is a rare disorder. It is the source of a diagnostic hardship as it is difficult to distinguish from other lesions. We report an unusual case with multiple affected sites both in hands and the right big toe.
A 42-year-old female initially presented with two painful tumefactions affecting the left third finger and the right middle finger. These tumefactions had been present for two months. Conventional radiography and computed tomography of the hand revealed soft tissue swelling with bone expansion and cortical destruction in the proximal, middle and distal phalanx of the third finger, the proximal phalanx of the middle finger in the left hand, the proximal and middle phalanx of the middle finger of the right hand. Bone scintigraphy showed additionally infraradiologic localisation in the proximal phalanx of the first right toe. Pathology examination of a biopsy specimen revealed granulomatous osteitis with caseous necrosis. Antituberculosis treatment led to initial clinical remission followed by a recurrence and lesion spreading due to bacteria resistance. The second line treatment with Rifampicine, Ciprofloxacine, Ethambutol and Clarithromycine induced favorable outcome.
Tuberculosis dactylitis is well tolerated for a long time leading to a late diagnosis which may favour its spreading. Antituberculosis treatment is effective but the functional outcome depends on early diagnosis.
结核性指(趾)炎(TD)是一种罕见疾病。它是诊断难题的根源,因为很难与其他病变区分开来。我们报告一例不寻常病例,双手及右大脚趾均有多处受累。
一名42岁女性最初表现为左手中指和右手环指出现两个疼痛性肿块。这些肿块已存在两个月。手部的传统X线摄影和计算机断层扫描显示,左手环指近节、中节和远节指骨、左手中指近节指骨、右手中指近节和中节指骨出现软组织肿胀伴骨质膨胀和皮质破坏。骨闪烁显像还显示右足第一趾近节指骨有放射线下定位。活检标本的病理检查显示为肉芽肿性骨炎伴干酪样坏死。抗结核治疗导致最初的临床缓解,但随后因细菌耐药而复发并出现病变扩散。利福平、环丙沙星、乙胺丁醇和克拉霉素的二线治疗取得了良好效果。
结核性指(趾)炎在很长一段时间内耐受性良好,导致诊断延迟,这可能有利于其扩散。抗结核治疗有效,但功能结果取决于早期诊断。