Zhou Jian, Yang Xuanjie, Hu Yong, Li Shijun
School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China.
Guizhou Center for Disease Control and Prevention, Guiyang, China.
Epidemiol Infect. 2025 Jan 21;153:e26. doi: 10.1017/S095026882400150X.
Multiple osteoarticular tuberculosis (MOT) represents an uncommon yet severe form of tuberculosis, characterized by a lack of systematic analysis and comprehension. Our objective was to delineate MOT's epidemiological characteristics and establish a scientific foundation for prevention and treatment. We conducted searches across eight databases to identify relevant articles. Pearson's chi-square test (Fisher's exact test) and Bonferroni method were employed to assess osteoarticular involvement among patients of varying age and gender (α = 0.05). The study comprised 98 articles, encompassing 151 cases from 22 countries, with China and India collectively contributing 67.55% of cases. MOT predominantly affected individuals aged 0-30 years (58.94%). Pulmonary tuberculosis was evident in 16.55% of cases, with spinal involvement prevalent (57.62%). Significant differences were noted in trunk, spine, thoracic, and lumbar vertebrae involvement, as well as type I lesions across age groups, increasing with age. Moreover, significant differences were observed in upper limb bone involvement and type II lesions across age groups, decreasing with age. Gender differences were not significant. MOT primarily manifests in China and India, predominantly among younger individuals, indicating age-related variations in osteoarticular involvement. Enhanced clinical awareness is crucial for accurate MOT diagnosis, mitigating missed diagnoses and misdiagnoses.
多发性骨关节结核（MOT）是一种罕见但严重的结核病形式，其特点是缺乏系统的分析和理解。我们的目的是描述MOT的流行病学特征，并为预防和治疗奠定科学基础。我们在八个数据库中进行检索以识别相关文章。采用Pearson卡方检验（Fisher精确检验）和Bonferroni方法评估不同年龄和性别的患者骨关节受累情况（α = 0.05）。该研究包括98篇文章，涵盖来自22个国家的151例病例，中国和印度合计占病例的67.55%。MOT主要影响0至30岁的个体（58.94%）。16.55%的病例有肺结核，脊柱受累常见（57.62%）。各年龄组在躯干、脊柱、胸椎和腰椎受累以及I型病变方面存在显著差异，随年龄增长而增加。此外，各年龄组在上肢骨受累和II型病变方面也存在显著差异，随年龄增长而减少。性别差异不显著。MOT主要在中国和印度表现突出，主要发生在年轻人中，表明骨关节受累存在与年龄相关的差异。提高临床意识对于准确诊断MOT、减少漏诊和误诊至关重要。
