综述：干细胞在卵巢发育、功能及疾病中的作用
Minireview: stem cell contribution to ovarian development, function, and disease.
作者信息
Tilly Jonathan L, Rueda Bo R
机构信息
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA.
出版信息
Endocrinology. 2008 Sep;149(9):4307-11. doi: 10.1210/en.2008-0458. Epub 2008 Jun 12.
Abstract
By virtue of the fact that oocytes not only serve to produce embryos after fertilization but also can effectively reprogram adult somatic cell nuclei to a pluripotent state, much of the interest in the role of stem cells in ovarian biology has been focused on the germline. However, very recent studies have revealed that somatic stem cells may also be of considerable relevance to the study of normal ovarian function. Furthermore, stem cell dysfunction may underlie or contribute to disease states such as ovarian cancer and polycystic ovary syndrome. Our objective is to explore these concepts in greater detail, with the hope of stimulating further research efforts into understanding what role stem cells may play in the physiology and pathology of the mammalian female gonads.
摘要
由于卵母细胞不仅在受精后用于产生胚胎，还能有效地将成体体细胞的细胞核重编程为多能状态，因此干细胞在卵巢生物学中的作用研究大多集中在生殖系。然而，最近的研究表明，体细胞干细胞可能也与正常卵巢功能的研究密切相关。此外，干细胞功能障碍可能是卵巢癌和多囊卵巢综合征等疾病状态的基础或促成因素。我们的目标是更详细地探讨这些概念，希望能激发更多的研究工作，以了解干细胞在哺乳动物雌性性腺的生理和病理过程中可能发挥的作用。
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