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Minireview: hormones and mammary cell fate--what will I become when I grow up?综述：激素与乳腺细胞命运——我长大后会变成什么样？
Endocrinology. 2008 Sep;149(9):4317-21. doi: 10.1210/en.2008-0450. Epub 2008 Jun 12.
2
Stem cells and the stem cell niche in the breast: an integrated hormonal and developmental perspective.乳腺中的干细胞与干细胞微环境：激素与发育的综合视角
Stem Cell Rev. 2007 Jun;3(2):147-56. doi: 10.1007/s12015-007-0019-1.
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On mammary stem cells.关于乳腺干细胞。
J Cell Sci. 2005 Aug 15;118(Pt 16):3585-94. doi: 10.1242/jcs.02532.
4
Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment.胚胎和成人的乳腺发育：形态发生和定型旅程的新见解。
Development. 2020 Nov 15;147(22):dev169862. doi: 10.1242/dev.169862.
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Active allies: hormones, stem cells and the niche in adult mammopoiesis.活跃的盟友：激素、干细胞和成人造血中的龛位。
Trends Endocrinol Metab. 2012 Jun;23(6):299-309. doi: 10.1016/j.tem.2012.04.002. Epub 2012 May 19.
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Mammary gland development: cell fate specification, stem cells and the microenvironment.乳腺发育：细胞命运决定、干细胞与微环境。
Development. 2015 Mar 15;142(6):1028-42. doi: 10.1242/dev.087643.
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Morphogenesis of mammary gland development.乳腺发育的形态发生
Adv Exp Med Biol. 2004;554:219-28. doi: 10.1007/978-1-4757-4242-8_19.
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Molecular regulators of pubertal mammary gland development.青春期乳腺发育的分子调控因素。
Ann Med. 2011 May;43(3):212-34. doi: 10.3109/07853890.2011.554425. Epub 2011 Mar 20.
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Mammary gland development.乳腺发育
Wiley Interdiscip Rev Dev Biol. 2012 Jul-Aug;1(4):533-57. doi: 10.1002/wdev.35.

引用本文的文献

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Changes in the mammary gland during aging and its links with breast diseases.随着年龄增长，乳腺的变化及其与乳腺疾病的关系。
Acta Biochim Biophys Sin (Shanghai). 2023 May 15;55(6):1001-1019. doi: 10.3724/abbs.2023073.
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Cysteine Dioxygenase Regulates the Epithelial Morphogenesis of Mammary Gland via Cysteine Sulfinic Acid.半胱氨酸双加氧酶通过半胱氨酸亚磺酸调节乳腺上皮形态发生。
iScience. 2019 Mar 29;13:173-189. doi: 10.1016/j.isci.2019.02.011. Epub 2019 Feb 18.
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Mammosphere Culture of Mammary Cells from Cynomolgus Macaques ().食蟹猴乳腺细胞的乳腺球培养（）
Comp Med. 2019 Apr 1;69(2):144-150. doi: 10.30802/AALAS-CM-18-000030. Epub 2019 Feb 7.
4
Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules.人乳腺组织中祖细胞的解剖定位显示未成熟小叶内未分化细胞富集。
Breast Cancer Res. 2014 Oct 15;16(5):453. doi: 10.1186/s13058-014-0453-3.
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IGF-IR mediated mammary tumorigenesis is enhanced during pubertal development.在青春期发育过程中，胰岛素样生长因子-1受体（IGF-IR）介导的乳腺肿瘤发生会增强。
PLoS One. 2014 Sep 26;9(9):e108781. doi: 10.1371/journal.pone.0108781. eCollection 2014.
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Unraveling the regulatory connections between two controllers of breast cancer cell fate.揭示乳腺癌细胞命运的两个调控因子之间的调控联系。
Nucleic Acids Res. 2014 Jun;42(11):6839-49. doi: 10.1093/nar/gku360. Epub 2014 May 3.
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Comparison of the transcriptomes of long-term label retaining-cells and control cells microdissected from mammary epithelium: an initial study to characterize potential stem/progenitor cells.长期标记保留细胞和乳腺上皮细胞微分离对照细胞转录组的比较：初步研究特征潜在的干细胞/祖细胞。
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Epigenetic modifications unlock the milk protein gene loci during mouse mammary gland development and differentiation.在小鼠乳腺发育和分化过程中，表观遗传修饰会使乳蛋白基因座解锁。
PLoS One. 2013;8(1):e53270. doi: 10.1371/journal.pone.0053270. Epub 2013 Jan 2.
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p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF.过表达 Cas 会损害雌激素和 EGF 反应下的乳腺分支形态发生。
PLoS One. 2012;7(12):e49817. doi: 10.1371/journal.pone.0049817. Epub 2012 Dec 11.
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Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling.Elf5 通过影响 Notch 信号来调节乳腺干细胞/祖细胞命运。
Stem Cells. 2012 Jul;30(7):1496-508. doi: 10.1002/stem.1112.

本文引用的文献

1
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.醛脱氢酶1（ALDH1）是正常和恶性人乳腺干细胞的标志物，也是临床预后不良的预测指标。
Cell Stem Cell. 2007 Nov;1(5):555-67. doi: 10.1016/j.stem.2007.08.014.
2
The Ets transcription factor Elf5 specifies mammary alveolar cell fate.Ets转录因子Elf5决定乳腺腺泡细胞的命运。
Genes Dev. 2008 Mar 1;22(5):581-6. doi: 10.1101/gad.1614608.
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Mammary development in the embryo and adult: a journey of morphogenesis and commitment.胚胎期和成年期的乳腺发育：形态发生与细胞分化的历程
Development. 2008 Mar;135(6):995-1003. doi: 10.1242/dev.005439.
4
Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells.TP63与刺猬信号通路之间的上皮内相互作用调节乳腺干细胞祖细胞精细分化的静止和激活。
Stem Cells. 2008 May;26(5):1253-64. doi: 10.1634/stemcells.2007-0691. Epub 2008 Feb 21.
5
BRCA1 regulates human mammary stem/progenitor cell fate.BRCA1基因调控人类乳腺干细胞/祖细胞的命运。
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1680-5. doi: 10.1073/pnas.0711613105. Epub 2008 Jan 29.
6
Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage.雌激素对乳腺发育和乳腺癌的调节作用：双调蛋白成为焦点。
Breast Cancer Res. 2007;9(4):304. doi: 10.1186/bcr1740.
7
Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer.正向交叉调节环将GATA-3与乳腺癌中的雌激素受体α表达联系起来。
Cancer Res. 2007 Jul 1;67(13):6477-83. doi: 10.1158/0008-5472.CAN-07-0746.
8
Alveolar progenitor cells develop in mouse mammary glands independent of pregnancy and lactation.肺泡祖细胞在小鼠乳腺中发育，与怀孕和哺乳无关。
J Cell Physiol. 2007 Sep;212(3):729-36. doi: 10.1002/jcp.21071.
9
Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland.乳腺中雌激素受体表达与体内干细胞活性的解离。
J Cell Biol. 2007 Jan 1;176(1):19-26. doi: 10.1083/jcb.200604065. Epub 2006 Dec 26.
10
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation.Gata-3是乳腺形态发生和管腔细胞分化的重要调节因子。
Nat Cell Biol. 2007 Feb;9(2):201-9. doi: 10.1038/ncb1530. Epub 2006 Dec 24.

综述：激素与乳腺细胞命运——我长大后会变成什么样？

Minireview: hormones and mammary cell fate--what will I become when I grow up?

作者信息

LaMarca Heather L, Rosen Jeffrey M

机构信息

Department of Molecular and Cellular Biology, DeBakey Building M638a, Houston, Texas 77030, USA.

出版信息

Endocrinology. 2008 Sep;149(9):4317-21. doi: 10.1210/en.2008-0450. Epub 2008 Jun 12.

DOI:10.1210/en.2008-0450
PMID:18556345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2553372/
Abstract

Systemic hormones are key regulators of postnatal mammary gland development and play an important role in the etiology and treatment of breast cancer. Mammary ductal morphogenesis is controlled by circulating hormones, and these same hormones are also critical mediators of mammary stem cell fate decisions. Recent studies have helped further our understanding of the origin, specification, and fate of mammary stem cells during postnatal development. Here we review recent studies on the involvement of hormone receptors and several transcription factors in mammary stem/progenitor cell differentiation and lineage commitment.

摘要

全身性激素是出生后乳腺发育的关键调节因子，在乳腺癌的病因学和治疗中发挥重要作用。乳腺导管形态发生受循环激素控制，而这些相同的激素也是乳腺干细胞命运决定的关键介质。最近的研究有助于我们进一步了解出生后发育过程中乳腺干细胞的起源、特化和命运。在这里，我们综述了关于激素受体和几种转录因子参与乳腺干/祖细胞分化和谱系定向的最新研究。