Inman Jamie L, Robertson Claire, Mott Joni D, Bissell Mina J
Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.
Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
Development. 2015 Mar 15;142(6):1028-42. doi: 10.1242/dev.087643.
The development of the mammary gland is unique: the final stages of development occur postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of the female, the mammary gland can undergo many rounds of expansion and proliferation. The mammary gland thus provides an excellent model for studying the 'stem/progenitor' cells that allow this repeated expansion and renewal. In this Review, we provide an overview of the different cell types that constitute the mammary gland, and discuss how these cell types arise and differentiate. As cellular differentiation cannot occur without proper signals, we also describe how the tissue microenvironment influences mammary gland development.
其发育的最后阶段在出生后青春期时，受激素信号影响而发生。此外，在雌性的一生中，乳腺会经历多轮的扩张和增殖。因此，乳腺为研究允许这种反复扩张和更新的“干细胞/祖细胞”提供了一个绝佳模型。在本综述中，我们概述了构成乳腺的不同细胞类型，并讨论了这些细胞类型如何产生和分化。由于没有适当的信号就无法发生细胞分化，我们还描述了组织微环境如何影响乳腺发育。
