使用雷奈酸锶使骨转换向有利于骨形成的方向重新平衡：对骨强度的影响。
Rebalancing bone turnover in favour of formation with strontium ranelate: implications for bone strength.
作者信息
Fonseca J E
机构信息
Rheumatology Research Unit, Instituto de Medicina Molecular, Edifício Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028 Lisboa, Portugal.
出版信息
Rheumatology (Oxford). 2008 Jul;47 Suppl 4(Suppl 4):iv17-19. doi: 10.1093/rheumatology/ken165.
Abstract
This review updates our current knowledge on the mechanism of action of strontium ranelate and analyses the way it rebalances bone turnover and how it influences bone biomechanics. Strontium ranelate is able to increase pre-osteoblast replication, osteoblast differentiation, collagen type I synthesis and bone matrix mineralization probably through a calcium-sensing receptor (CaR)-dependent mechanism. Paralleling this anabolic effect there is inhibition of osteoclast differentiation and activity mediated by an increase in osteoprotegerin (OPG) and a decrease in RANK ligand (RANKL). The overall effect is a rebalanced bone turnover in favour of improved bone geometry, cortical thickness, trabecular bone morphology and intrinsic bone tissue quality, which translates into enhanced bone strength.
摘要
本综述更新了我们目前关于雷奈酸锶作用机制的知识，并分析了其重新平衡骨转换的方式以及对骨生物力学的影响。雷奈酸锶可能通过钙敏感受体（CaR）依赖性机制增加前成骨细胞复制、成骨细胞分化、I型胶原蛋白合成和骨基质矿化。与这种合成代谢作用同时发生的是，通过骨保护素（OPG）增加和核因子κB受体活化因子配体（RANKL）减少介导破骨细胞分化和活性受到抑制。总体效果是骨转换重新平衡，有利于改善骨几何形态、皮质厚度、小梁骨形态和骨组织内在质量，从而增强骨强度。
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本文引用的文献
1
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Bone. 2008 Jan;42(1):129-38. doi: 10.1016/j.bone.2007.08.043. Epub 2007 Sep 12.
2
Histomorphometric and microCT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate.
J Bone Miner Res. 2008 Feb;23(2):215-22. doi: 10.1359/jbmr.071012.
3
Osteoblasts and bone formation.
Acta Reumatol Port. 2007 Apr-Jun;32(2):103-10.
4
Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength.
J Bone Miner Res. 2007 Sep;22(9):1419-25. doi: 10.1359/jbmr.070607.
5
The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation.
Biochem Pharmacol. 2007 Aug 1;74(3):438-47. doi: 10.1016/j.bcp.2007.04.020. Epub 2007 Apr 27.
6
Induction of a program gene expression during osteoblast differentiation with strontium ranelate.
Biochem Biophys Res Commun. 2007 Apr 6;355(2):307-11. doi: 10.1016/j.bbrc.2007.01.120. Epub 2007 Jan 30.
7
The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis.
FASEB J. 2006 Dec;20(14):2562-4. doi: 10.1096/fj.06-6304fje. Epub 2006 Oct 31.
8
Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation.
Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:S11-5. doi: 10.1097/01.bor.0000229522.89546.7b.
9
Bone quality--the material and structural basis of bone strength and fragility.
N Engl J Med. 2006 May 25;354(21):2250-61. doi: 10.1056/NEJMra053077.
10
Strontium ranelate: a physiological approach for an improved bone quality.
Bone. 2006 Feb;38(2 Suppl 1):15-8. doi: 10.1016/j.bone.2005.09.023.
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