Liang Yongqiang, Li Haoyan, Xu Jiang, Li Xin, Qi Mengchun, Hu Min
Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, China.
College of Stomatology, Hebei United University, Tangshan 063000, China.
Int J Mol Sci. 2014 Jun 4;15(6):9952-62. doi: 10.3390/ijms15069952.
Surface modification techniques have been applied to generate titanium implant surfaces that promote osseointegration for use in dental applications. In this study, strontium-doped brushite coatings were deposited on titanium by electrochemical deposition. The phase composition of the coating was investigated by energy dispersive X-ray spectroscopy and X-ray diffraction. The surface morphologies of the coatings were studied through scanning electron microscopy, and the cytocompatibility and bioactivity of the strontium-doped brushite coatings were evaluated using cultured osteoblasts. Osteoblast proliferation was enhanced by the addition of strontium, suggesting a possible mechanism by which strontium incorporation in brushite coatings increased bone formation surrounding the implants. Cell growth was also strongly influenced by the composition of the deposited coatings, with a 10% Sr-doped brushite coating inducing the greatest amount of bone formation among the tested materials.
表面改性技术已被应用于生成促进骨整合的钛植入物表面，用于牙科应用。在本研究中，通过电化学沉积在钛上沉积了掺锶透钙磷石涂层。通过能量色散X射线光谱和X射线衍射研究了涂层的相组成。通过扫描电子显微镜研究了涂层的表面形貌，并使用培养的成骨细胞评估了掺锶透钙磷石涂层的细胞相容性和生物活性。添加锶可增强成骨细胞增殖，这表明掺锶透钙磷石涂层中锶的掺入增加植入物周围骨形成的一种可能机制。细胞生长也受到沉积涂层组成的强烈影响，在测试材料中，10%掺锶透钙磷石涂层诱导的骨形成量最大。
