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通过电化学沉积法进行锶涂层处理可改善骨质疏松模型中植入物的骨整合情况。

Strontium coating by electrochemical deposition improves implant osseointegration in osteopenic models.

作者信息

Liang Yongqiang, Li Haoyan, Xu Jiang, Li Xin, Li Xinchang, Yan Yuting, Qi Mengchun, Hu Min

机构信息

College of Stomatology, Hebei United University, Tangshan, Hebei 063000, P.R. China ; Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, P.R. China.

College of Stomatology, Hebei United University, Tangshan, Hebei 063000, P.R. China.

出版信息

Exp Ther Med. 2015 Jan;9(1):172-176. doi: 10.3892/etm.2014.2038. Epub 2014 Oct 30.

DOI:10.3892/etm.2014.2038
PMID:25452797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4247308/
Abstract

Osteopenia, a preclinical state of osteoporosis, restricts the application of adult orthodontic implant anchorage and tooth implantation. Strontium (Sr) is able to promote bone formation and inhibit bone absorption. The aim of the present study was to evaluate a new method for improving the success rate of dental implantation. In this study, an electrochemical deposition (ECD) method was used to prepare a Sr coating on a titanium implant. The coating composition was investigated by energy dispersive X-ray spectroscopy and X-ray diffraction, and the surface morphology of the coating was studied using scanning electron microscopy. A total of 24 Sprague-Dawley rats received bilateral ovariectomy (OVX) and an additional 12 rats underwent a sham surgery. All rats were then implanted in the bilateral tibiae with titanium mini-implants with or without a Sr coating. The results of histological examination and a fluorescence double labeling assay showed strong new bone formation with a wider zone between the double labels, a higher rate of bone mineralization and better osseointegration in the OVX rats that received Sr-coated implants compared with the OVX rats that received uncoated implants. The study indicates that Sr coatings are easily applied by an ECD method, and that Sr coatings have a promoting effect on implant osseointegration in animals with osteopenia.

摘要

骨质减少作为骨质疏松症的一种临床前状态，限制了成人正畸种植支抗和牙齿种植的应用。锶（Sr）能够促进骨形成并抑制骨吸收。本研究的目的是评估一种提高牙种植成功率的新方法。在本研究中，采用电化学沉积（ECD）方法在钛种植体上制备锶涂层。通过能量色散X射线光谱和X射线衍射研究涂层成分，并使用扫描电子显微镜研究涂层的表面形态。总共24只Sprague-Dawley大鼠接受双侧卵巢切除术（OVX），另外12只大鼠接受假手术。然后给所有大鼠双侧胫骨植入有或无锶涂层的微型钛种植体。组织学检查和荧光双标记分析结果显示，与接受未涂层种植体的OVX大鼠相比，接受锶涂层种植体的OVX大鼠有更强的新骨形成，双标记之间的区域更宽，骨矿化率更高，骨整合更好。该研究表明，锶涂层可通过ECD方法轻松施加，并且锶涂层对骨质减少动物的种植体骨整合有促进作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fac/4247308/9307d4434f13/ETM-09-01-0172-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fac/4247308/1b45d28b9eba/ETM-09-01-0172-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fac/4247308/46c8cee53e7e/ETM-09-01-0172-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fac/4247308/f3113ddd9de2/ETM-09-01-0172-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fac/4247308/9307d4434f13/ETM-09-01-0172-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fac/4247308/1b45d28b9eba/ETM-09-01-0172-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fac/4247308/46c8cee53e7e/ETM-09-01-0172-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fac/4247308/f3113ddd9de2/ETM-09-01-0172-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fac/4247308/9307d4434f13/ETM-09-01-0172-g03.jpg

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