Hoffman Robert P
Division of Pediatric Endocrinology, Department of Pediatrics, The Ohio State University College of Medicine Children's Hospital, Columbus, OH 43205, USA.
J Pediatr Endocrinol Metab. 2008 Apr;21(4):323-8. doi: 10.1515/jpem.2008.21.4.323.
In adults with growth hormone (GH) deficiency (GHD), GH treatment restores impaired endothelial function, a precursor of cardiovascular disease. Its effect in children with GHD is unknown.
Three months of GH (0.3 mg/kg/wk) were given to nine children with GHD. Endothelial function was measured via reactive hyperemic response. Forearm blood flow (FBF, strain gauge plethysmography) was measured before and after 5 min of upper arm arterial occlusion. Blood pressure and lipid, insulin and glucose levels were measured. Pretreatment endothelial function was compared to 18 previously studied control children.
Percent fall in forearm vascular resistance was greater in controls (81.2 +/- 1.9%) than in children with GHD (69.6 +/- 5.3%, p = 0.021) but was not affected by GH (60.6 +/- 7.5%). GH markedly increased HOMAIR (21 +/- 7 versus 43 +/- 8, p = 0.004). Plasma lipid levels did not significantly differ.
These results indicate that endothelial function is impaired in children with GHD. GH therapy does not restore the impairment.
在生长激素（GH）缺乏（GHD）的成人中，GH治疗可恢复受损的内皮功能，而内皮功能受损是心血管疾病的先兆。其对GHD儿童的影响尚不清楚。
对9名GHD儿童给予3个月的GH（0.3mg/kg/周）治疗。通过反应性充血反应测量内皮功能。在上臂动脉闭塞5分钟前后测量前臂血流量（FBF，应变计体积描记法）。测量血压、血脂、胰岛素和血糖水平。将治疗前的内皮功能与18名先前研究的对照儿童进行比较。
对照组前臂血管阻力下降百分比（81.2±1.9%）高于GHD儿童（69.6±5.3%，p = 0.021），但不受GH影响（60.6±7.5%）。GH显著增加HOMAIR（21±7对43±8，p = 0.004）。血浆脂质水平无显著差异。
这些结果表明GHD儿童的内皮功能受损。GH治疗不能恢复这种损害。
