Zierhut M, Thiel H J, Pleyer U, Waetjen R, Weidle E G
Abteilung Allgemeine Augenheilkunde mit Poliklinik, Universitäts-Augenklinik, Tübingen, Bundesrepublik Deutschland.
Fortschr Ophthalmol. 1991;88(2):161-4.
In animal studies, bromocriptine (Pravidel) has demonstrated immunosuppression because of inhibition of prolactin. After publication of positive results in the treatment of uveitis in a few case reports and in an uncontrolled study we conducted a double-blind placebo-controlled study in 13 patients with chronic recurrent anterior uveitis who had experienced three or more recurrences during the previous year. Therapy was started gradually during the symptom-free interval and continued for 1 year with 2.5 mg twice daily. Two recurrences or relevant side effects led to discontinuation of the therapy. In the bromocriptine group, 2 of 7 patients had no recurrences during the study period. Two patients had to stop because of two recurrences but, in contrast to earlier recurrences, they responded to local corticosteriod treatment within a few days. The remaining 3 patients (1 with one recurrence, 2 without) had to stop because of the side effects (arterial hypotension, arthritic complaints). In 5 of 6 patients in the placebo group treatment was stopped because of recurrences and in 1 patients because she believed she was experiencing a side effect from bromocriptine (breast atrophy). In summary, bromocriptine seems to have a prophylactic effect on anterior uveitis. Side effects were frequent but mild compared to other immunosuppressives. In case of arterial hypotension, additional therapy could make this drug more tolerable.
在动物研究中，溴隐亭（帕罗西汀）已显示出因抑制催乳素而具有免疫抑制作用。在一些病例报告和我们进行的一项非对照研究中公布了其治疗葡萄膜炎的阳性结果后，我们对13例慢性复发性前葡萄膜炎患者进行了一项双盲安慰剂对照研究，这些患者在前一年经历了三次或更多次复发。在无症状期逐渐开始治疗，并以每日两次2.5毫克的剂量持续治疗1年。两次复发或相关副作用导致治疗中断。在溴隐亭组中，7例患者中有2例在研究期间未复发。两名患者因两次复发而不得不停药，但与早期复发不同的是，他们在几天内对局部皮质类固醇治疗有反应。其余3例患者（1例复发1次，2例未复发）因副作用（动脉低血压、关节炎症状）而不得不停药。安慰剂组6例患者中有5例因复发而停药，1例患者因认为自己出现了溴隐亭的副作用（乳房萎缩）而停药。总之，溴隐亭似乎对前葡萄膜炎有预防作用。与其他免疫抑制剂相比，副作用频繁但较轻。在动脉低血压的情况下，额外的治疗可以使这种药物更易于耐受。
