Seite Jean-François, Shoenfeld Yehuda, Youinou Pierre, Hillion Sophie
Immunology and Pathology Research Unit, Medical School, Brest, France.
Autoimmun Rev. 2008 Jun;7(6):435-9. doi: 10.1016/j.autrev.2008.04.012. Epub 2008 May 2.
Intravenous immunoglobulins (IVIg) consist of IgG concentrated from pooled plasma of numerous donors. Their contents is variable, depending in part on the method of preparation. Natural antibodies and natural autoantibodies are prominent in these preparations and their function. Among these, are the idiotype (Id)/anti-Id dimers. Attention has recently been paid to Fc-gamma receptors and sialylation of the IgG from IVIg.
静脉注射免疫球蛋白(IVIg)由从众多供体的混合血浆中浓缩的IgG组成。其成分可变,部分取决于制备方法。天然抗体和天然自身抗体在这些制剂及其功能中很突出。其中包括独特型(Id)/抗独特型二聚体。最近人们关注了IVIg中IgG的Fc-γ受体和唾液酸化。