混合人免疫球蛋白含有与系统性红斑狼疮相关的4B4交叉反应独特型具有反应性的抗独特型。
Pooled human immunoglobulins contain anti-idiotypes with reactivity against the SLE-associated 4B4 cross-reactive idiotype.
作者信息
DeKeyser F, DeKeyser H, Kazatchkine M D, Rossi F, Dang H, Talal N
机构信息
University of Texas Health Science Center, Department of Medicine, San Antonio, USA.
出版信息
Clin Exp Rheumatol. 1996 Nov-Dec;14(6):587-91.
OBJECTIVE
To identify anti-idiotype antibody activity against a regulatory anti-Sm idiotype (4B4) in pooled human IgG (IVIG).
METHODS
ELISA were used to determine anti-idiotype antibody activity in IVIG.
RESULTS
Anti-idiotype antibody activity to 4B4 was detected in IVIG. The anti-idiotypic activity in IVIG could be inhibited by antigen, Sm, and rabbit anti-idiotypic antiserum. The idiotypic binding activity was predominately directed against the 4B4 VH region.
CONCLUSION
IVIG contains antibodies against a lupus-associated crossreactive idiotype. These antibodies represent Ab2 beta type antibodies. The anti-idiotypic activity in IVIG may be relevant to the efficacious use of IVIG in treating rheumatic diseases.
目的
鉴定人免疫球蛋白（IVIG）中针对调节性抗Sm独特型（4B4）的抗独特型抗体活性。
方法
采用酶联免疫吸附测定法（ELISA）检测IVIG中的抗独特型抗体活性。
结果
在IVIG中检测到针对4B4的抗独特型抗体活性。IVIG中的抗独特型活性可被抗原Sm和兔抗独特型抗血清抑制。独特型结合活性主要针对4B4 VH区。
结论
IVIG含有针对狼疮相关交叉反应独特型的抗体。这些抗体代表Ab2β型抗体。IVIG中的抗独特型活性可能与IVIG在治疗风湿性疾病中的有效应用有关。
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