Eisenbrand G, Blankart M, Sommer H, Weber B
Department of Food Chemistry and Environmental Toxicology, University of Kaiserslautern, Germany.
IARC Sci Publ. 1991(105):238-41.
A method has been developed for the determination of the N-nitrosoalkanolamines, N-nitrosodiethanolamine (NDELA) and N-nitrosobis(2-hydroxypropyl)amine (NDHPA) in cosmetics. In model systems, we studied nitrosation of the most relevant precursors by NaNO2, by the preservatives Bronopol and Bronidox and by nitric oxides. Secondary amines were most rapidly nitrosated, and Bronopol, Bronidox and atmospheric nitric oxides appeared to be the most relevant nitrosating agents. In order to remove the most important sources of contamination, the Federal Health Office issued an official recommendation to producers to avoid use of secondary amines in cosmetics (March, 1987). Analysis of cosmetics taken from the German market 6-18 months later showed that only 19/126 samples were contaminated with NDELA (12-235 micrograms/kg or NDHPA (40-215 micrograms/kg). The results reflect a strong downward trend in contamination.
已开发出一种测定化妆品中 N-亚硝基链烷醇胺、N-亚硝基二乙醇胺（NDELA）和 N-亚硝基双（2-羟丙基）胺（NDHPA）的方法。在模型系统中，我们研究了亚硝酸钠、防腐剂溴硝醇和溴化硝以及一氧化氮对最相关前体的亚硝化作用。仲胺的亚硝化速度最快，溴硝醇、溴化硝和大气中的一氧化氮似乎是最相关的亚硝化剂。为了消除最重要的污染源，联邦卫生局于 1987 年 3 月向生产商发布了官方建议，避免在化妆品中使用仲胺。6 至 18 个月后对从德国市场采集的化妆品进行分析表明，只有 19/126 个样品被 NDELA（12 - 235 微克/千克）或 NDHPA（40 - 215 微克/千克）污染。结果反映出污染呈强劲下降趋势。
