Lewis David, Mama John, Hawkes Jamie
Perachem Limited, 1 Sizers Court, Henshaw Lane, Yeadon, Leeds LS19 7DP, UK.
Materials (Basel). 2013 Feb 13;6(2):517-534. doi: 10.3390/ma6020517.
This review discusses a new aspect to the safety profile of oxidative hair dyes using data already in the public domain. These dyes contain secondary amines that are capable of forming potentially carcinogenic nitrosamine derivatives when exposed to atmospheric pollution. Numerous scientific articles confirm the existence of secondary amines in hair dyes (and their intermediates), the possibility of nitrosation by atmospheric NO of secondary amines to give the nitrosamines, and the significant safety risks on -nitrosamines. It is believed that such nitrosamine derivatives should be investigated more fully in the interests of consumer safety.
本综述利用已公开的数据讨论了氧化型染发剂安全性的一个新方面。这些染发剂含有仲胺，当暴露于大气污染中时，仲胺能够形成潜在致癌的亚硝胺衍生物。大量科学文章证实了染发剂（及其中间体）中存在仲胺，大气中的一氧化氮可使仲胺亚硝化生成亚硝胺，以及亚硝胺存在重大安全风险。人们认为，为了消费者安全，应对此类亚硝胺衍生物进行更全面的研究。
