N-苯甲酰腙的三氟甲基化反应。
Trifluoromethylation of N-benzoylhydrazones.
作者信息
Dilman Alexander D, Arkhipov Dmitry E, Levin Vitalij V, Belyakov Pavel A, Korlyukov Alexander A, Struchkova Marina I, Tartakovsky Vladimir A
机构信息
N.D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Russian Federation.
出版信息
J Org Chem. 2008 Jul 18;73(14):5643-6. doi: 10.1021/jo800782w. Epub 2008 Jun 18.
PMID:18558768
Abstract
A method for the nucleophilic trifluoromethylation of N-benzoylhydrazones using Me3SiCF3/AcONa has been described. The CN bond of the hydrazones is activated by difluoroboron group, which is introduced by means of boron trifluoride and allylsilane.
摘要
已经描述了一种使用三甲基硅基三氟甲烷（Me3SiCF3）/醋酸钠（AcONa）对N-苯甲酰腙进行亲核三氟甲基化的方法。腙的C=N键通过二氟硼基团活化，该基团通过三氟化硼和烯丙基硅烷引入。
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