Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Org Lett. 2010 Nov 5;12(21):5060-3. doi: 10.1021/ol1023135.
A copper-mediated oxidative cross-coupling of aryl- and alkenylboronic acids with (trifluoromethyl)trimethylsilane (Me(3)SiCF(3)) under mild conditions has been developed. This method allows a wide range of functional group tolerant trifluoromethylated arenes and alkenes to be easily prepared. This oxidative trifluoromethylation has the potential to introduce trifluoromethyl groups into advanced, highly functionalized organic molecules.
发展了一种温和条件下铜介导的芳基和烯基硼酸与（三氟甲基）三甲基硅烷（Me3SiCF3）的氧化交叉偶联反应。该方法允许广泛的官能团容忍的三氟甲基化芳烃和烯烃很容易制备。这种氧化三氟甲基化有可能将三氟甲基基团引入到先进的、高度官能化的有机分子中。
