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手性膦配体-锌(II)配合物催化不对称曼尼希型反应合成二氟烯氧硅烷腙。

Asymmetric catalytic Mannich-type reaction of hydrazones with difluoroenoxysilanes using imidazoline-anchored phosphine ligand-zinc(II) complexes.

机构信息

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China.

出版信息

Org Biomol Chem. 2012 Apr 7;10(13):2509-13. doi: 10.1039/c2ob07022g. Epub 2012 Feb 15.

DOI:10.1039/c2ob07022g
PMID:22334290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3667584/
Abstract

Asymmetric Mannich-type reaction of hydrazones with difluoroenoxysilanes using chiral zinc(II)-imidazoline-phosphine complexes as catalysts have been established, giving the corresponding adducts in good to excellent enantioselectivity and chemical yields under mild conditions.

摘要

手性锌（II）-咪唑啉-膦配合物作为催化剂，实现了水合腙与二氟烯氧硅烷的不对称 Mannich 型反应，在温和条件下以良好到优异的对映选择性和化学收率得到了相应的加合物。

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Indium(I)-catalyzed asymmetric allylation, crotylation, and alpha-chloroallylation of hydrazones with rare constitutional and high configurational selectivities.铟（I）催化腙的不对称烯丙基化、巴豆基化和α-氯烯丙基化反应，具有罕见的结构选择性和高构型选择性。
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