Frei E, Hassel M, Spiegelhalder B, Wiessler M
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
IARC Sci Publ. 1991(105):358-61.
The nasal carcinogen N-nitrodimethylamine was reduced to its N-nitroso analogue N-nitrosodimethylamine in vivo. Liver-soluble fraction and brain mitochondria contained enzymes capable of reducing this compound. The activity was only partly inhibited by oxygen; NADPH and NADH served as cosubstrates. N-Nitromethylamine is also carcinogenic and was reduced by liver cytoplasm to a protein binding species (methyldiazohydroxide?).
