Subcellular fractions of rat organs contain nitroreductases which reduce N-nitrodimethylamine to N-nitrosodimethylamine.
作者信息
Frei E, Hassel M, Spiegelhalder B, Wiessler M
机构信息
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
出版信息
IARC Sci Publ. 1991(105):358-61.
PMID:1855880
Abstract
The nasal carcinogen N-nitrodimethylamine was reduced to its N-nitroso analogue N-nitrosodimethylamine in vivo. Liver-soluble fraction and brain mitochondria contained enzymes capable of reducing this compound. The activity was only partly inhibited by oxygen; NADPH and NADH served as cosubstrates. N-Nitromethylamine is also carcinogenic and was reduced by liver cytoplasm to a protein binding species (methyldiazohydroxide?).
摘要
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