Gomez-Lopez A, Zaragoza O, Dos Anjos Martins M, Melhem M C, Rodriguez-Tudela J L, Cuenca-Estrella M
Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda (Madrid),
Clin Microbiol Infect. 2008 Jul;14(7):727-30. doi: 10.1111/j.1469-0691.2008.02021.x.
The data available in the literature concerning Cryptococcus gattii in vitro antifungal susceptibility are contradictory. We have analyzed the activity of eight antifungal agents against 23 C. gattii clinical isolates and compared the susceptibility profiles with those of C. neoformans. MIC analysis (mg/L) revealed that C. gattii isolates were more susceptible to amphotericin B and flucytosine than were C. neoformans isolates. Fluconazole and other azole compounds showed high MIC values for C. gattii. Posaconazole displayed good activity. Further studies are required to ascertain the predictive value of the in vitro data presented here.
文献中关于加氏隐球菌体外抗真菌药敏性的数据相互矛盾。我们分析了8种抗真菌药物对23株加氏隐球菌临床分离株的活性，并将药敏谱与新生隐球菌的进行了比较。最低抑菌浓度（MIC）分析（mg/L）显示，加氏隐球菌分离株比新生隐球菌分离株对两性霉素B和氟胞嘧啶更敏感。氟康唑和其他唑类化合物对加氏隐球菌显示出高MIC值。泊沙康唑表现出良好的活性。需要进一步研究以确定此处给出的体外数据的预测价值。
