Torella M, Tammaro C, Auriemma S, Zurzolo L, Natullo V, Scaffa C, De Franciscis P, Panariello S
III Clinica Ostetrica e Ginecologica, Seconda Università degli Studi di Napoli, Napoli, Italy.
Minerva Ginecol. 2008 Aug;60(4):281-5.
The aim of this study was to verify the effects on endometrium of short-term phytoestrogens therapy in postmenopausal women.
This randomized study compared two groups of 50 patients undergone respectively to phytoestrogens therapy or placebo. An endometrial survey was performed on the study groups by ultrasound and hysteroscopy at baseline and at 6 and 12 months.
The ultrasonographic findings and the hysteroscopic biopsies in the 47 women submitted to phytoestrogens therapy that completed the follow-up showed an atrophic and/or inactive endometrial mucosa less than in one patients (2.1%) with endometrial thickness and proliferative endometrium bioptical sample after 12 months of treatment; no cases of endometrial hyperplasia were found.
In the authors' 12 month experience, phytoestrogens therapy in postmenopausal women was safe for endometrial stimulation because did not cause any significant alteration of the mucosa in a short-term administration.
本研究旨在验证短期植物雌激素疗法对绝经后女性子宫内膜的影响。
这项随机研究比较了两组各50例分别接受植物雌激素疗法或安慰剂治疗的患者。在基线以及6个月和12个月时，通过超声和宫腔镜对研究组进行子宫内膜检查。
在完成随访的接受植物雌激素治疗的47名女性中，超声检查结果和宫腔镜活检显示，与1例（2.1%）患者相比，治疗12个月后子宫内膜厚度及增殖期子宫内膜活检样本显示萎缩和/或无活性的子宫内膜黏膜较少；未发现子宫内膜增生病例。
根据作者12个月的经验，绝经后女性使用植物雌激素疗法对子宫内膜刺激是安全的，因为短期给药不会引起黏膜的任何显著改变。
