Yu Si, He Xiao Shun, Ma Yi
Department of Gastroenterology, The 6th Affiliated Hospital, Guangzhou, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2008 Jun 18;40(3):327-9.
To investigate the techniques of establishment of abdominal heart transplantation model in rats and modify the procedure to make it more stable and improve the success rate.
Heterotopic abdominal heart transplantations of Wistar and SD rats were performed by using Ono's method with modification of preparation of recipients, donor cardiectomy and donor transplantations.
One hundred heart transplantations were performed, among which 90 were successful. The success rate was 90%.
This modified Ono's method can shorten the ischemia time and recipient abdominal aorta occlusion time, make vessel anastomosis easier and increase the success rate of operation. It is a stable and reliable model of heart transplantations in rats.
探讨大鼠腹部心脏移植模型的建立技术，并对手术方法进行改进，使其更稳定并提高成功率。
采用改良的小野（Ono）法对Wistar大鼠和SD大鼠进行异位腹部心脏移植，对受体准备、供体心脏切除及供体移植操作进行了改进。
共进行100例心脏移植手术，其中90例成功。成功率为90%。
这种改良的小野法可缩短缺血时间和受体腹主动脉阻断时间，使血管吻合更容易，提高手术成功率。它是一种稳定可靠的大鼠心脏移植模型。
