Bueno O, Bueno G, Moreno L A, Nuviala R J, Pérez-González J M, Bueno M
Departamento de Pediatría, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
Nutr Hosp. 2008 May-Jun;23(3):212-9.
To analyse the effect of zinc supplementation in growth and nutritional status of a homogeneous group of newborns with intra uterine growth retardation and asymmetric growth. The effect of changes of zinc status on growth and leptin serum concentrations was also analysed.
A double blind, randomised clinical trial was designed in order to detect differences in growth between zinc and placebo groups during the first 6 months of life. 31 infants were included either to the zinc group (n = 14) (38.8+/-1.4 weeks GA, 2,171+/-253 g body weight) or the placebo group (n = 17) (38.9+/-1.1 weeks GA, 2,249+/-220 g body weight). The zinc group received a supplement of 3 mg elemental zinc per day (as zinc sulphate).
There were not significant differences between groups for anthropometric measurements through the study period. We found a significant effect of the study group, in hair zinc concentrations, but not in serum zinc concentrations; post-hoc comparisons for hair zinc revealed that there were significant differences between groups at 1, 2, and 6 months of age. Changes in serum and hair zinc concentrations from baseline to 6 months, showed significant correlations with changes in weight/age and length/age z-scores, in the supplement group. Changes in leptin serum concentrations during follow-up, showed significant correlations with changes in sum of 4 skinfolds and weight/age z-score, in the placebo group. Changes in hair zinc concentration through the study period showed significant correlations with changes in leptin serum concentrations from baseline to 6 months of follow-up.
In a homogeneous group of intra uterine growth retardation infants with asymmetric growth, 3 mg/day zinc supplementation do not show significant improvements in weight and length growth. Changes in zinc status were related with changes in weight and length during the first 6 months of life. Changes in leptin serum concentrations were related with changes in the anthropometric indices of body fat accretion.
分析补锌对一组宫内生长受限且生长不对称的同质新生儿生长及营养状况的影响。同时分析锌状态变化对生长及血清瘦素浓度的影响。
设计一项双盲随机临床试验，以检测锌组和安慰剂组在出生后前6个月生长情况的差异。31名婴儿被纳入锌组（n = 14）（孕龄38.8±1.4周，体重2171±253克）或安慰剂组（n = 17）（孕龄38.9±1.1周，体重2249±220克）。锌组每天补充3毫克元素锌（以硫酸锌形式）。
在整个研究期间，两组间人体测量指标无显著差异。我们发现研究组对头发锌浓度有显著影响，但对血清锌浓度无显著影响；头发锌的事后比较显示，1、2和6月龄时两组间存在显著差异。补充组中，血清和头发锌浓度从基线到6个月的变化与体重/年龄和身长/年龄z评分的变化显著相关。安慰剂组中，随访期间血清瘦素浓度的变化与4个皮褶厚度之和及体重/年龄z评分的变化显著相关。研究期间头发锌浓度的变化与随访基线至6个月血清瘦素浓度的变化显著相关。
在一组宫内生长受限且生长不对称的同质婴儿中，每天补充3毫克锌对体重和身长增长未显示出显著改善。锌状态的变化与出生后前6个月体重和身长的变化有关。血清瘦素浓度的变化与身体脂肪堆积的人体测量指标变化有关。
