Leach D C
Division of Endocrinology and Metabolism, Henry Ford Hospital, Detroit, MI 48202.
Henry Ford Hosp Med J. 1991;39(1):18-21.
Treatment with human growth hormone (GH) at Henry Ford Hospital began in 1964 and has included 145 patients. A total of 68 patients were treated with extracted hormone and 77 with recombinant GH. The appearance of Creutzfeldt-Jakob disease, now five cases worldwide, in patients treated with extracted hormone abruptly stopped its use in the United States. The development of recombinant GH in 1985 has resulted in greater availability of treatment. Diagnostic criteria are now more liberal and certain patients without GH deficiency, i.e., those with the Turner syndrome, are now being successfully treated with GH. GH is expensive and its inappropriate use would have a major impact on health care costs. Indications for its use are not yet fully elucidated.
1964年，亨利·福特医院开始使用人类生长激素（GH）进行治疗，共有145名患者接受了治疗。其中68名患者接受了提取激素治疗，77名患者接受了重组GH治疗。接受提取激素治疗的患者中出现了克雅氏病，目前全球共有5例，这使得提取激素在美国突然停止使用。1985年重组GH的研发使治疗的可及性更高。现在诊断标准更加宽松，一些没有GH缺乏症的患者，即患有特纳综合征的患者，现在正在成功地接受GH治疗。GH价格昂贵，其不当使用将对医疗保健成本产生重大影响。其使用指征尚未完全阐明。
