Scurry W Cooper, McGinn Johnathan D
Piedmont Ear, Nose & Throat Associates, Winston-Salem, NC 27103, USA.
Ear Nose Throat J. 2008 Jun 13;87(6):E8-11.
Recurrent respiratory papillomatosis is a benign neoplastic process involving squamous epithelium of the respiratory tract, typically the vocal folds. In cases of aggressive growth, or uncontrolled disease, airway compromise and respiratory distress can occur. Human papillomavirus (HPV) is known to be the etiologic agent in this disease process, as well as in condyloma acuminata, or genital warts. Studies have shown that HPV-induced condyloma acuminata can worsen during pregnancy. We present a case of airway obstruction requiring emergent tracheostomy in a pregnant patient with known laryngeal recurrent respiratory papillomatosis. The management of this condition and some theories regarding its response to certain hormonal states are discussed.
复发性呼吸道乳头状瘤病是一种良性肿瘤性病变,累及呼吸道的鳞状上皮,通常是声带。在生长迅速或疾病无法控制的情况下,可出现气道受压和呼吸窘迫。人乳头瘤病毒(HPV)已知是该疾病过程以及尖锐湿疣(即生殖器疣)的病原体。研究表明,HPV引起的尖锐湿疣在妊娠期会加重。我们报告一例患有已知喉部复发性呼吸道乳头状瘤病的孕妇出现气道阻塞,需要紧急行气管切开术的病例。本文讨论了该疾病的处理方法以及关于其对某些激素状态反应的一些理论。