洋葱伯克霍尔德菌复合体脂多糖的化学和生物学特性
Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides.
作者信息
De Soyza Anthony, Silipo Alba, Lanzetta Rosa, Govan John R, Molinaro Antonio
机构信息
Transplantation and Immunobiology Group, Institute of Cellular Medicine, Newcastle University and The Freeman Hospital, Newcastle-upon-Tyne, UK.
出版信息
Innate Immun. 2008 Jun;14(3):127-44. doi: 10.1177/1753425908093984.
The Burkholderia cepacia complex comprises 10 closely related Gram-negative organisms all of which appear capable of causing disease in humans. These organisms appear of particular relevance to patients with cystic fibrosis. Lipopolysaccharide (LPS) is an important virulence determinant in Gram-negative pathogens. In this review, we highlight important data within the field commenting on LPS/lipid A structure-to-function relationships and cytokine induction capacity of Burkholderia strains studied so far.
洋葱伯克霍尔德菌复合体由10种密切相关的革兰氏阴性菌组成，所有这些细菌似乎都能够在人类中引起疾病。这些细菌对于囊性纤维化患者似乎具有特别的相关性。脂多糖（LPS）是革兰氏阴性病原体中的一种重要毒力决定因素。在本综述中，我们着重介绍了该领域内的重要数据，这些数据涉及到迄今为止所研究的伯克霍尔德菌菌株的LPS/脂质A结构与功能的关系以及细胞因子诱导能力。
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