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碳酸锂治疗情感障碍作用机制的神经生物学考量?

Neurobiological Considerations of the mode of action of lithium carbonate in the treatment of affective disorders?

作者信息

Bunney W E, Murphy D L

出版信息

Pharmakopsychiatr Neuropsychopharmakol. 1976 May;9(3):142-7. doi: 10.1055/s-0028-1094489.

Abstract

The effects of lithium on membrane function and cellular processes are considered in relation to lithium's physiochemical properties. Several cellular regulatory functions, including cyclic AMP formation and metabolism and biogenic amine neurotransmitter metabolism, are examined as possible mechanisms whereby lithium might exert its mood stabilizing actions. The necessity for understanding lithium's interactions with "receptors" - the molecular sites affected by lithium - in considering its pre-and post-synapatic effects in stressed.

摘要

锂对膜功能和细胞过程的影响是根据锂的物理化学性质来考虑的。研究了几种细胞调节功能,包括环磷酸腺苷的形成、代谢以及生物胺神经递质代谢,作为锂可能发挥其情绪稳定作用的潜在机制。在考虑锂在应激状态下的突触前和突触后效应时,了解锂与“受体”(受锂影响的分子位点)相互作用的必要性。

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