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[恶性胸腔积液的外科治疗]

[Surgical therapy for malignant pleural effusions].

作者信息

Ludwig C, Stoelben E

机构信息

Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH.

出版信息

Zentralbl Chir. 2008 Jun;133(3):218-21. doi: 10.1055/s-2008-1076788.

Abstract

Symptomatic malignant pleural effusions are common in patients with neoplastic disease (50 %). Frequently, they are a sign of advanced disease. These patients have an average life expectancy of 3 to 12 months. The therapeutic aim should be an efficient treatment with a short hospital stay. Chest tube drainage gives rapid relief of symptoms and information on the expansion of the lungs. When complete expansion of the lung is possible, VATS insufflation of talc is recommended. Talc is the most effective sclerosant (80 %) followed by doxycycline (70 %). VATS pleurodesis has a higher complication rate but is more effective than a talc slurry instilled through the chest tube. When the lung is trapped, long-term indwelling pleural drainage and pleuroperitoneal shunts are alternatives.

摘要

有症状的恶性胸腔积液在肿瘤疾病患者中很常见(50%)。通常,它们是疾病进展的标志。这些患者的平均预期寿命为3至12个月。治疗目标应该是进行有效的治疗并缩短住院时间。胸腔闭式引流能迅速缓解症状并提供肺部扩张的信息。当肺部有可能完全复张时,建议通过电视辅助胸腔镜手术(VATS)注入滑石粉。滑石粉是最有效的硬化剂(有效率80%),其次是强力霉素(有效率70%)。VATS胸膜固定术的并发症发生率较高,但比通过胸腔闭式引流管注入滑石粉悬液更有效。当肺被包裹时,长期留置胸腔引流和胸膜-腹膜分流术是替代方案。

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