Batista M, Niño T, Alamo D, González F, Santana M, Rodríguez N, Cabrera F, Gracia A
Reproduction and Obstetrics, Veterinary Faculty, University of Las Palmas de Gran Canaria, Spain.
Reprod Domest Anim. 2009 Feb;44(1):83-7. doi: 10.1111/j.1439-0531.2007.01001.x. Epub 2008 Jun 19.
Pregnant goats were induced to parturition on day 145 of pregnancy, with three different protocols: group Cl (n = 19) was injected intramuscularly (IM) with 75 microg of the prostaglandin analogue R-Cloprostenol; group L (n = 20) was treated IM with 7.5 mg of the prostaglandin analogue Luprostiol; group L(50) (n = 18) was injected IM with 3.75 mg of Luprostiol (IM); in addition, Group S (Control, n = 15) was injected IM with 1 ml of saline solution. Thereafter, goats were continuously observed to record the following parameters: parturition, dystocia incidence, placental delivery and kid and maternal survival. Moreover, blood sampling was performed around kidding and plasma progesterone concentrations were analyzed. The interval from injection to parturition (mean +/- SEM) was not significantly different among the experimental groups: 35.1 +/- 1.5 h, 33.3 +/- 0.9 h and 34.1 +/- 1.8 h (groups Cl, L and L(50), respectively). In the control group, time to parturition was 99.4 +/- 12.1 h (range: 34-166 h). All the goats expelled the foetal membranes within the first 2 h after the induction. The incidence of dystocia due to foetal posture was not significantly different between induced and control goats (21.1%, 20.0%, 22.0% and 20%, for groups Cl, L, L(50) and S, respectively). The percentage of live kids was practically similar between induced goats (93.9%, 94.9% and 92.1%, for groups Cl, L and L(50), respectively); in addition, there was a case of maternal mortality in control group (6.7%; 1/15), whereas there was no mortality in induced goats (0%; 0/57). Plasma concentrations of progesterone showed an intense drop (<2 ng/ml) at 24 h after induction. This study confirms the effectiveness of the luprostiol to induce the parturition in goats, within a narrow range (30-40 h) in most of the induced females (80.0%, 7.5 mg; 77.8%, 3.75 mg).
怀孕山羊在妊娠第145天通过三种不同方案诱导分娩：C1组（n = 19）肌肉注射75微克前列腺素类似物R-氯前列醇；L组（n = 20）肌肉注射7.5毫克前列腺素类似物鲁前列醇；L(50)组（n = 18）肌肉注射3.75毫克鲁前列醇；此外，S组（对照组，n = 15）肌肉注射1毫升生理盐水。此后，持续观察山羊以记录以下参数：分娩、难产发生率、胎盘娩出以及羔羊和母羊存活情况。此外，在产羔前后进行采血并分析血浆孕酮浓度。各实验组从注射到分娩的间隔时间（均值±标准误）无显著差异：分别为35.1±1.5小时、33.3±0.9小时和34.1±1.8小时（C1组、L组和L(50)组）。对照组分娩时间为99.4±12.1小时（范围：34 - 166小时）。所有山羊在诱导后2小时内排出胎膜。诱导组和对照组因胎儿姿势导致的难产发生率无显著差异（C1组、L组、L(50)组和S组分别为21.1%、20.0%、22.0%和20%）。诱导组存活羔羊的百分比实际相近（C1组、L组和L(50)组分别为93.9%、94.9%和92.1%）；此外，对照组有1例母羊死亡（6.7%；1/15），而诱导组无死亡（0%；0/57）。诱导后24小时血浆孕酮浓度急剧下降（<2纳克/毫升）。本研究证实鲁前列醇在大多数诱导母羊（80.0%，7.5毫克；77.8%，3.75毫克）中能在较窄时间范围（30 - 40小时）内有效诱导山羊分娩。
