Kaeoket K
Faculty of Veterinary Science, Mahidol University, Nakorn-pathom, Thailand.
Reprod Domest Anim. 2006 Oct;41(5):472-6. doi: 10.1111/j.1439-0531.2006.00674.x.
The aims of the present study were to further examine the efficacy of different doses and routes of R-cloprostenol administration on the parturition response in sows. Fifty crossbred multiparous sows (Landrace x Yorkshire) with an average parity number of 4.7 +/- 2.4 were allocated to induce farrowing by one of the following treatments: Group I (control, n = 10) injection with normal saline 2 ml administered intramuscularly (i.m.); Group II (n = 10) injection with 75 microg of R-cloprostenol administered i.m. (at 7 AM); Group III (n = 10) injection with 75 microg of R-cloprostenol (at 7 AM) together with 10 IU of oxytocin (24 h after injection of R-cloprostenol) administered i.m.; Group IV (n = 10) injection with 37.5 microg of R-cloprostenol (at 7 AM) administered into perivulva region; Group V (n = 10) injection with 37.5 microg of R-cloprostenol (at 7 AM) administered into perivulva region together with 10 IU of oxytocin (24 h after injection of R-cloprostenol) administered i.m. The following parameters: pre-farrowing maternal behaviour, restless behaviour, R-cloprostenol or oxytocin injection to farrowing interval, expulsion intervals, duration of farrowing, total number of piglets born, litter birthweight, umbilical cord morphology and the degree of meconium staining were record. There were no significant differences among groups for the pre-farrowing maternal behaviours. In all the sows, the restless behaviour was not observed. There were no significant effect of oxytocin administration (10 IU, i.m.) on the percentage of umbilical cord morphology and the degree of meconium staining in different groups. There were no significant effect of route and dose of administration on the number of total piglet born, piglet born alive, stillbirth, mummy and litter birthweight. No significant effects of the different groups were found on the R-cloprostenol and oxytocin injection to farrowing interval, expulsion interval and farrowing duration. In conclusion, the present results demonstrated that a half dose (37.5 microg) of R-cloprostenol administered into the perivulva region was effective for inducing farrowing as the full recommended dose (75 microg) administered into the neck region (i.m.) and with no restless behaviour.
本研究的目的是进一步检验不同剂量和给药途径的R-氯前列醇对母猪分娩反应的效果。50头平均胎次为4.7±2.4的杂交经产母猪（长白猪×约克夏猪）被分配接受以下一种处理来诱导分娩：第一组（对照组，n = 10）肌肉注射2 ml生理盐水；第二组（n = 10）上午7点肌肉注射75 μg R-氯前列醇；第三组（n = 10）上午7点肌肉注射75 μg R-氯前列醇，并在注射R-氯前列醇24小时后肌肉注射10 IU催产素；第四组（n = 10）将37.5 μg R-氯前列醇注射到阴门周围区域；第五组（n = 10）将37.5 μg R-氯前列醇注射到阴门周围区域，并在注射R-氯前列醇24小时后肌肉注射10 IU催产素。记录以下参数：产前母性行为、躁动行为、R-氯前列醇或催产素注射至分娩间隔、排出间隔、分娩持续时间、出生仔猪总数、窝出生体重、脐带形态和胎粪污染程度。产前母性行为在各组之间没有显著差异。在所有母猪中，均未观察到躁动行为。催产素（10 IU，肌肉注射）对不同组脐带形态百分比和胎粪污染程度没有显著影响。给药途径和剂量对出生仔猪总数、活产仔猪数、死胎、木乃伊胎和窝出生体重没有显著影响。不同组对R-氯前列醇和催产素注射至分娩间隔、排出间隔和分娩持续时间没有显著影响。总之，目前的结果表明，将半剂量（37.5 μg）的R-氯前列醇注射到阴门周围区域与全推荐剂量（75 μg）肌肉注射到颈部区域一样有效，且不会引起躁动行为。
