Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, Cabrera F, Gracia A
Obstetrics and Reproduction, Arucas, Spain Unit of Surgery, Faculty of Veterinary of Las Palmas, Arucas, Spain.
Reprod Domest Anim. 2011 Oct;46(5):882-8. doi: 10.1111/j.1439-0531.2011.01759.x. Epub 2011 Feb 15.
This study assessed the efficacy of aglepristone at inducing parturition in pregnant goats. Six experimental groups were defined: group A-5 (n = 12), group A-3.3 (n = 12), group A-2.5 (n = 12) and group A-1.5 (n = 12) in which goats were injected SC once with 5.0, 3.3, 2.5 and 1.5 mg of aglepristone per kg body weight of goat, respectively, group L (n = 11), which was treated IM with 3.75 mg of luprostiol; and group Ct (n = 11), which was injected SC with 1 ml of saline solution. Different parameters associated with parturition were thereafter investigated. In addition, plasma progesterone concentrations were defined after treatments till parturition. Aglepristone effectively induced parturition in all of the goats. In the A-5, A-3.3 and A-2.5 groups, the time to parturition was around 30-34 h, and the majority of goats (97.2%, 35/36) started kidding between 25 and 40 h after the aglepristone injection. However, the goats in group A-1.5 showed a significantly (p < 0.01) higher time to parturition (mean: 46.8 h). Overall, the incidence of dystocia registered in aglepristone-induced goats (20.8%, 10/48) and luprostiol-induced goats was not different from that observed after a spontaneous parturition. The percentage of live kids was very similar between A-5, A-3.3, A.2.5 and L groups (95.7, 95.3, 95.0 and 96.3%, respectively) but was higher that observed in the control (83.4%) and A-1.5 (81.2%) groups. In addition, no maternal mortality was registered in any groups. No changes in plasma progesterone were observed during the first 24 h after treatment, and high plasma progesterone concentrations were present at kidding (6.7, 5.5, 4.5 and 3.6 ng/ml for groups A-5, A-3.3, A-2.5 and A-1.5, respectively), confirming that aglepristone does not induce parturition via luteolysis. This study demonstrates that aglepristone can be used to induce parturition in goats with satisfactory efficacy, inducing pregnancy termination without direct or immediate modifications of luteal function.
本研究评估了阿格来司酮诱导妊娠山羊分娩的效果。定义了六个实验组：A - 5组（n = 12）、A - 3.3组（n = 12）、A - 2.5组（n = 12）和A - 1.5组（n = 12），分别给山羊皮下注射每千克体重5.0、3.3、2.5和1.5毫克的阿格来司酮；L组（n = 11），肌肉注射3.75毫克氯前列醇；Ct组（n = 11），皮下注射1毫升盐溶液。此后研究了与分娩相关的不同参数。此外，确定了治疗后至分娩期间的血浆孕酮浓度。阿格来司酮能有效诱导所有山羊分娩。在A - 5、A - 3.3和A - 2.5组中，分娩时间约为30 - 34小时，大多数山羊（97.2%，35/36）在注射阿格来司酮后25至40小时开始产仔。然而，A - 1.5组的山羊分娩时间显著更长（p < 0.01）（平均：46.8小时）。总体而言，阿格来司酮诱导分娩的山羊（20.8%，10/48）和氯前列醇诱导分娩的山羊难产发生率与自然分娩后观察到的情况无差异。A - 5、A - 3.3、A - 2.5和L组的活仔百分比非常相似（分别为95.7%、95.3%、95.0%和96.3%），但高于对照组（83.4%）和A - 1.5组（81.2%）。此外，所有组均未记录到母羊死亡。治疗后最初24小时内未观察到血浆孕酮变化，分娩时血浆孕酮浓度较高（A - 5、A - 3.3、A - 2.5和A - 1.5组分别为6.7、5.5、4.5和3.6纳克/毫升），证实阿格来司酮不是通过黄体溶解诱导分娩。本研究表明，阿格来司酮可用于诱导山羊分娩，效果令人满意，可在不直接或立即改变黄体功能的情况下终止妊娠。
