从泰国呼吸道感染患者中分离出的肺炎链球菌的抗菌药敏性。

Antimicrobial susceptibility of Streptococcus pneumoniae isolated from patients with respiratory tract infections in Thailand.

作者信息

Srifuengfung Somporn, Tribuddharat Chanwit, Champreeda Preecha, Daniels Justin, Chokephaibulkit Kulkanya, Wongwan Nithita, Polwichai Pitimon

机构信息

Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 2008 May;39(3):461-6.

PMID:18564685

Abstract

A total of 400 clinical Streptococcus pneumoniae strains from patients with respiratory diseases were collected from January 2002 to December 2005. In this study, an increased prevalence of penicillin-nonsusceptible S. pneumoniae (PNSP) from 63% in 2002-2003 to 69% in 2004-2005 was found. During 2004-2005, 56% were erythromycin-nonsusceptible S. pneumoniae (ENSP) and 54% were both PNSP and ENSP. The PNSP, ENSP and PNSP+ENSP groups showed similar trends, ie, sensitive to amoxicillin/clavulanate (range 97.2-98.5%), levofloxacin (range 90.7-92.4%), ceftriaxone (range 87.1-89.4%), and ofloxacin (range 64.8-66.1%). Lower levels of susceptibility were detected for azithromycin, clarithromycin, cefdinir, cefprozil, clindamycin, co-trimoxazole, chloramphenicol and tetracycline in penicillin and erythromycin-nonsusceptible strains. Of the macrolide-resistant S. pneumoniae, 55% of strains exhibited the M phenotype and 45% the constitutive MLS(B) phenotype. No pneumococci with the inducible MLS(B) phenotype were detected in Thailand.

摘要

2002年1月至2005年12月期间，共收集了400株来自呼吸道疾病患者的临床肺炎链球菌菌株。在本研究中，发现青霉素不敏感肺炎链球菌（PNSP）的患病率从2002 - 2003年的63%上升至2004 - 2005年的69%。在2004 - 2005年期间，56%为红霉素不敏感肺炎链球菌（ENSP），54%为PNSP且ENSP。PNSP、ENSP和PNSP + ENSP组呈现相似趋势，即对阿莫西林/克拉维酸敏感（范围97.2 - 98.5%）、左氧氟沙星（范围90.7 - 92.4%）、头孢曲松（范围87.1 - 89.4%）和氧氟沙星（范围64.8 - 66.1%）。在青霉素和红霉素不敏感菌株中，阿奇霉素、克拉霉素、头孢地尼、头孢丙烯、克林霉素、复方新诺明、氯霉素和四环素的敏感性较低。在耐大环内酯类肺炎链球菌中，55%的菌株表现为M表型，45%为组成型MLS(B)表型。在泰国未检测到具有诱导型MLS(B)表型的肺炎球菌。