拉伸可调节人牙周膜细胞中的弹力纤维。
Stretching modulates oxytalan fibers in human periodontal ligament cells.
作者信息
Tsuruga E, Nakashima K, Ishikawa H, Yajima T, Sawa Y
机构信息
Section of Functional Structure, Department of Morphological Biology, Division of Biomedical Sciences, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka, Japan.
出版信息
J Periodontal Res. 2009 Apr;44(2):170-4. doi: 10.1111/j.1600-0765.2008.01099.x. Epub 2008 Jun 17.
MATERIAL AND METHODS
We subjected periodontal ligament fibroblasts to stretching strain to examine the effects on their formation of oxytalan fibers in cell/matrix layers.
RESULTS
Stretching increased the levels of fibrillin-1 and fibrillin-2 by 25% relative to the control, but did not affect the gene expression level of either type of fibrillin. Immunofluorescence and immunogold electron microscopy analysis revealed that bundles of oxytalan fibers became thicker under stretching conditions.
CONCLUSION
These results suggest that tension strain functionally regulates microfibril assembly in periodontal ligament fibroblasts and thus may contribute to the homeostasis of oxytalan fibers in periodontal ligaments.
材料与方法
我们对牙周膜成纤维细胞施加拉伸应变，以研究其对细胞/基质层中耐酸性纤维形成的影响。
结果
与对照组相比，拉伸使原纤蛋白-1和原纤蛋白-2的水平提高了25%，但两种原纤蛋白的基因表达水平均未受影响。免疫荧光和免疫金电子显微镜分析显示，在拉伸条件下耐酸性纤维束变粗。
结论
这些结果表明，张应变在功能上调节牙周膜成纤维细胞中的微原纤维组装，因此可能有助于牙周膜中耐酸性纤维的稳态。
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