Guitera P, Li L X, Crotty K, Fitzgerald P, Mellenbergh R, Pellacani G, Menzies S W
Department of Dermatology, Sydney Melanoma Diagnostic Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Br J Dermatol. 2008 Aug;159(2):364-9. doi: 10.1111/j.1365-2133.2008.08681.x. Epub 2008 Jun 28.
Ultrasound at 20 MHz tends to overestimate melanoma Breslow thickness due to lymphocytic infiltration or naevus remnant. Objectives To determine the efficacy of 75-MHz ultrasound for estimating melanoma thickness and to assess its reliability to predict surgical requirement.
One hundred and twelve suspicious skin lesions were imaged prospectively with the 75-MHz ultrasound in A and B mode. This instrument has a penetration of 3 mm and a lateral resolution of 21 mum. Measurements were performed by two observers and the mean was compared with the histological Breslow thickness.
Forty-five of 52 melanomas and 22 of 36 naevi had clear hypoechogenicity boundaries. The median histological Breslow thickness of melanomas was 0.4 mm and 22 were in situ. The median percentage error of the machine was 13% of the histological Breslow thickness, with a high correlation (Pearson's r = 0.908, P < 0.001). Measurement was highly reliable for invasive melanoma, even in the presence of lymphocytic infiltration or naevus.
In this series, 75-MHz measurement was highly reliable for predicting invasive melanoma thickness.
由于淋巴细胞浸润或痣残留，20兆赫的超声往往会高估黑色素瘤的布雷斯洛厚度。目的：确定75兆赫超声估计黑色素瘤厚度的有效性，并评估其预测手术需求的可靠性。
用75兆赫超声A和B模式对112个可疑皮肤病变进行前瞻性成像。该仪器的穿透深度为3毫米，横向分辨率为21微米。由两名观察者进行测量，并将平均值与组织学布雷斯洛厚度进行比较。
52例黑色素瘤中的45例和36例痣中的22例有清晰的低回声边界。黑色素瘤的组织学布雷斯洛厚度中位数为0.4毫米，22例为原位黑色素瘤。机器的中位数百分比误差为组织学布雷斯洛厚度的13%，具有高度相关性（皮尔逊相关系数r = 0.908，P < 0.001）。即使存在淋巴细胞浸润或痣，对浸润性黑色素瘤的测量也高度可靠。
在本系列研究中，75兆赫测量对预测浸润性黑色素瘤厚度高度可靠。
