Karatosun V, Unver B, Ozden A, Ozay Z, Gunal I
Department of Orthopedic Surgery, Dokuz Eylul University Hospital, Balcova, Izmir, Turkey.
Clin Exp Rheumatol. 2008 Mar-Apr;26(2):288-94.
The goal of this study has been to determine whether hyaluronic acid (HA) or exercise therapy can improve functional parameters in patients with osteoarthritis (OA) of the ankle.
In a prospective clinical trial, 43 ankles (30 patients) with radiographic Kellgren Lawrence grade III OA were randomized to receive three intra-articular HA injections, with one-week interval of or exercise therapy for six weeks. Patients were evaluated by the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale and followed-up after 12 months.
Total AOFAS Ankle-Hindfoot score of OA patients has improved in both groups, varying from 61.6+/-16.8 to 90.1+/-9.7 with HA treatment and from 72.1+/-16.6 to 87.5+/-17.5 using exercise therapy at the end of the trial (p<0.01). There were no statistically significant differences between the groups.
This prospective randomized trial confirmed that, both HA injections and exercise therapy provide functional improvement. However, larger trials with longer follow-up are necessary for more definite conclusions.
本研究的目的是确定透明质酸（HA）或运动疗法是否能改善踝关节骨关节炎（OA）患者的功能参数。
在一项前瞻性临床试验中，将43例（30名患者）放射学检查为Kellgren Lawrence III级OA的踝关节随机分为两组，一组接受三次关节内HA注射，间隔一周，另一组进行为期六周的运动疗法。采用美国矫形足踝协会（AOFAS）踝-后足评分量表对患者进行评估，并在12个月后进行随访。
两组OA患者的AOFAS踝-后足总分均有所改善，试验结束时，HA治疗组从61.6±16.8提高到90.1±9.7，运动疗法组从72.1±16.6提高到87.5±17.5（p<0.01）。两组之间无统计学显著差异。
这项前瞻性随机试验证实，HA注射和运动疗法均可改善功能。然而，需要进行更大规模、随访时间更长的试验才能得出更明确的结论。
