Dybowski F, Sepp N, Bergerhausen H J, Braun J
Rheumazentrum Ruhrgebiet, St. Josef Krankenhaus, Herne, Germany.
Clin Exp Rheumatol. 2008 Mar-Apr;26(2):354-7.
Schnitzler's syndrome is a rather rare disease which may appear in a rheumatologist's office because patients often report rheumatic symptoms with joint, bone and muscle pain. However, it is characterized by chronic urticaria, recurrent fever, liver and spleen enlargement, osteosclerosis, and lymphadenopathy, in conjunction with a serum IgM M component. A patient who had been treated with relatively high doses of corticosteroids for 10 years with insufficient response was treated with the IL-1 receptor antagonist anakinra, this led to a complete resolution of symptoms.
施尼茨勒综合征是一种相当罕见的疾病，可能出现在风湿病科医生的诊室，因为患者经常诉说有风湿症状，伴有关节、骨骼和肌肉疼痛。然而，其特征为慢性荨麻疹、反复发热、肝脾肿大、骨硬化和淋巴结病，并伴有血清IgM M成分。一名患者曾接受相对高剂量的皮质类固醇治疗10年，但疗效不佳，后使用白细胞介素-1受体拮抗剂阿那白滞素进行治疗，症状完全缓解。
