Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211006584. doi: 10.1177/20587384211006584.
Interleukin-1 (IL-1) plays a key role in the pathogenesis of different rheumatic diseases. There are now several agents available on the market capable of blocking IL-1. The proven effectiveness and excellent safety of these drugs makes them a possible therapeutic option in the treatment of IL-1 driven diseases, when previous therapies are contraindicated or ineffective. This article discusses the European wide off-label use of these drugs for the treatment of rheumatic diseases.
白细胞介素-1(IL-1)在多种风湿性疾病的发病机制中起关键作用。目前市场上有几种能够阻断 IL-1 的药物。这些药物的疗效已得到证实,安全性良好,这使得它们成为以前的治疗方法有禁忌或无效时治疗 IL-1 驱动疾病的一种可能的治疗选择。本文讨论了这些药物在治疗风湿性疾病方面的欧洲超适应证使用情况。