Yarlagadda Sri G, Klein Christina L, Jani Alkesh
Department of Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT, USA.
Adv Chronic Kidney Dis. 2008 Jul;15(3):248-56. doi: 10.1053/j.ackd.2008.04.005.
Delayed graft function (DGF) describes dysfunction of the kidney allograft immediately after transplantation and is the most common complication in the immediate posttransplantation period. Although a standardized definition for DGF is lacking, it is most commonly defined as the need for dialysis within the first week after transplant. DGF is caused by a variety of factors related to the donor and recipient as well as organ procurement techniques. The occurrence of DGF affects both allograft and patient outcomes. In addition to prolonging hospital stay and increasing the costs associated with transplantation, DGF is associated with an increased incidence of acute rejection after transplantation and is associated with poorer long-term graft outcomes. Both immunologic and nonimmunologic mechanisms contribute to DGF. The risk factors for DGF that have been identified are reviewed as well as the impact of DGF on long-term outcomes.
移植肾功能延迟恢复（DGF）指肾移植术后即刻出现的移植肾失功，是移植术后早期最常见的并发症。尽管目前尚无DGF的标准化定义，但最常用的定义是移植后第一周内需要进行透析。DGF由多种与供体、受体以及器官获取技术相关的因素引起。DGF的发生会影响移植肾和患者的预后。除了延长住院时间和增加移植相关费用外，DGF还与移植后急性排斥反应的发生率增加有关，并且与较差的长期移植肾预后相关。免疫和非免疫机制均与DGF有关。本文综述了已确定的DGF危险因素以及DGF对长期预后的影响。
