Eknoyan Garabed
Renal Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030-3498, USA.
Adv Chronic Kidney Dis. 2008 Jul;15(3):308-13. doi: 10.1053/j.ackd.2008.04.010.
Acute kidney injury (AKI), a recently defined clinical entity, is an ailment that has afflicted humans from time immemorial. Its emergence as a disease follows by 50 years that of acute renal failure (ARF) after the Second World War. The medical model of ARF emerged as studies of the kidney in traumatic shock unraveled the pathophysiology of the disease and focused on its treatment with hemodialysis. ARF was reframed as AKI, based on the model that had been developed for chronic kidney disease, to incorporate the accrued epidemiologic data and present it as a public health model of disease that is potentially preventable and treatable at earlier stages of the disease.
急性肾损伤（AKI）是一种最近定义的临床病症，是一种自古以来就折磨人类的疾病。它作为一种疾病出现比第二次世界大战后急性肾衰竭（ARF）的出现晚了50年。随着对创伤性休克时肾脏的研究揭示了该疾病的病理生理学并将重点放在血液透析治疗上，ARF的医学模式应运而生。基于为慢性肾病所建立的模型，ARF被重新定义为AKI，以纳入积累的流行病学数据，并将其呈现为一种在疾病早期阶段具有潜在可预防性和可治疗性的公共卫生疾病模式。
